Dronabinol After Arthroscopic Surgery

Launched by NORTHWESTERN UNIVERSITY · Apr 13, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the use of a medication called dronabinol to help manage pain after knee surgery. Specifically, it's looking at whether dronabinol can reduce pain, decrease the need for stronger painkillers like opioids, and cause fewer side effects for patients undergoing arthroscopic surgery on the knee. Eligible participants are adults aged 18 and older who are scheduled for specific types of knee surgeries, such as removing damaged tissue or loose bodies.

If you join this study, you will receive dronabinol after your surgery and be monitored for your pain levels and any side effects. It’s important to know that you cannot participate if you are under 18, pregnant, or have certain medical conditions or allergies. Additionally, during the study, you will need to avoid using marijuana products and alcohol. This research could lead to better pain management options for knee surgery patients in the future, and if successful, the study may expand to include other types of surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18 years or older
• • Patient who will undergo arthroscopic surgery of the knee including, but not limited to,
• • Meniscectomy
• • Synovectomy
• • Chondroplasty
• • Loose body removal
• Exclusion Criteria:
• • Patients under age 18 years
• • Patients who cannot provide consent
• • Patients who are pregnant, breast feeding, or are trying to become pregnant during the study period
• • Patients with an allergy to any of the study drugs
• • Patient who are lactose-intolerant
• • Revision surgery
• • Open surgery
• • Comorbidities preventing surgery
• • Patients with a history of mania, depression, or schizophrenia
• • Patients taking any of the following drugs or supplements
• • Anticholinergic agents
• • Benzodiazepines
• • Central nervous system depressants
• • Droperidol
• • Hydroxyzine
• • Levomepromazine or methotrimeprazine
• • Monoamine oxidase inhibitors
• • Ritonavir
• • Selective serotonin reuptake inhibitors
• • Sympathomimetics
• • St. John's Wort
• • Current diagnosed alcohol or drug abuse
• • Patients who cannot or will not abide by the medication restrictions listed below
• • Medication restrictions
• • Participants must agree to abstain from using recreational or medical marijuana products or cannabidiol (CBD) in any form during the treatment period
• • Participants should not drink alcohol or take other drugs while taking the study drug or hydrocodone/acetaminophen