Hepatic and Systemic Hemodynamic Modeling During Liver Surgery

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Apr 15, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help doctors better understand how the liver handles blood flow during surgery. The goal is to create a mathematical model that can predict changes in a specific pressure difference (called the portocaval gradient) that can affect recovery after liver surgery. By improving the selection of patients for liver surgeries—like liver transplants or removing parts of the liver—the researchers hope to reduce the risks of serious complications, such as liver failure or death.

To participate in this trial, you need to be at least 18 years old and have a liver condition that requires surgery, such as a liver transplant or a procedure to remove part of your liver. You'll need to be enrolled in a social security plan and provide written consent to take part in the study. Participants can expect to undergo specific tests during their surgery to measure the pressure differences in the liver, which will help improve future surgeries for others. It's important to note that this study is not open to pregnant or breastfeeding women, or those who cannot undergo MRI scans.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Liver pathology requiring minor or major hepatectomy by laparotomy, or transplantation with small livers (graft weight/patient weight ratio \< 0. 01) or partial livers (living donor recipient or auxiliary grafts) or portal embolization (all patients scheduled for major hepatectomy on cirrhosis, or expanded hepatectomy on non-cirrhotic liver if and only if the ratio of future remaining liver/body weight is \<0.5.
• • Membership in a social security plan
• • Written consent to participate in this research
• • Adult patients (age ≥18 years)
• Exclusion Criteria:
• • Pregnant or breastfeeding women
• • Patient under guardianship or curatorship
• • Refusal to participate in the study
• • Contraindication to performing of MRI.
• • Patient Under State medical aid