Optimizing Graft Selection for ACL Reconstruction

Launched by HVIDOVRE UNIVERSITY HOSPITAL · Apr 18, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the best methods for reconstructing a damaged anterior cruciate ligament (ACL), which is a key ligament in the knee. The research aims to compare three common surgical techniques to determine which one works best for individual patients. Each year, around 2,500 people in Denmark undergo this surgery, but many still face issues like decreased knee function or even a repeat injury. By closely examining how different surgical approaches affect recovery and knee performance, the study hopes to find the most effective option.

To be eligible for this trial, participants should be between 18 and 40 years old and have a confirmed first-time ACL rupture that happened within the last two years. They should also have been physically active before the injury and want to return to that level of activity. Those who join the study will receive one of the three surgical treatments and will be monitored for up to two years to assess their knee function and overall quality of life through questionnaires and physical examinations. This research is important because it aims to improve surgical outcomes and help patients recover better after their ACL injuries.

Gender

ALL

Eligibility criteria

• • List of Inclusion criteria
• • clinically confirmed first-time ACL rupture
• • Current injury sustai´ned within 2 years
• • high activity level prior to ACL rupture (Tegner score ≥ 3) and personal goal of returning to physical activity.
• • List of preoperative exclusion criteria
• • Inadequate Danish language skills to answer questionnaires.
• • Prior ligament surgery in the injured knee
• • Prior ligament surgery in the non-injured knee
• • Instability of the non-injured knee
• • Known osteoarthritis (Kelgren Lawrence score ≥ 2)
• • Prior open surgery to either knee
• • Prior severe fracture involving knee joint surfaces
• • Prior severe injury to thigh muscles in either leg (e.g. tear or compartment)
• • Prior severe injury to the patella tendon of either knee (e.g. subluxation)
• • Medical condition preventing full participation (e.g. active cancer, - rheumatoid arthritis)
• • Psychiatric condition preventing full participation
• • Pregnancy
• • Obesity (BMI \> 30)
• • List of Perioperative exclusion criteria (Arthroscopy)
• • Medial meniscus lesion \> 50%
• • Lateral meniscus lesion \> 50%
• • Treated Meniscal root lesion or radial meniscal tear that require restrictive regimen
• • Cartilage lesion \>2cm2, Articular cartilage injury classification (ICRS) grade 3
• • Concurrent ligament injury (except medial collateral ligament (MCL) lesion grade 1-2)