Nifedipine Versus Magnesium Sulfate for Late Preterm Tocolysis

Launched by ASSIUT UNIVERSITY · Apr 19, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at two medications, nifedipine and magnesium sulfate (MgSO4), to see which one is better at helping pregnant women who are at risk of delivering their babies early, a condition known as threatened preterm labor. Specifically, the study will include women who are between 32 and 36 weeks pregnant and experiencing signs of early labor, such as frequent contractions. Participants will be randomly assigned to receive either nifedipine or magnesium sulfate, and both groups will also receive treatment to help their baby's lungs mature.

To be eligible for this trial, women must be 18 years or older and have specific signs of threatened preterm labor. However, certain conditions, like serious heart problems or infections, may prevent some women from participating. Throughout the study, women can expect to receive close monitoring and care as they receive their assigned treatment. Overall, the goal is to determine which medication is more effective in delaying delivery for these women, which is crucial for the health of both the mother and the baby.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Pregnant women with threatened preterm labor defined as 3 or more uterine contractions in 30 minutes confirmed by cardiotocography.
• • 2. Gestational age from 32 week + 0 days to (inclusive) 36 weeks + 0 days.
• • 3. Women with singleton or multiple pregnancy.
• • 4. Women with preterm prelabor rupture of membranes (PROM) will be included if they have uterine contractions.
• Exclusion Criteria:
• • 1. Contraindications for the use of either drugs, such as cardiac disease, hypotension, myasthenia gravis, or renal impairment.
• • 2. Contraindications for tocolysis, such as intrauterine demise, intrauterine infection, fetal distress, placental separation, or severe pre-eclampsia.
• • 3. Cervical dilatation \> 5 cm.
• • 4. Cervical length \> 30 mm by trans-vaginal ultrasound.
• • 5. Cervical cerclage.