Home Based Personalized Training and Video Consultation in Mitochondrial Myopathies: Study of Efficacy and Tolerance.

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE NICE · Apr 21, 2022

Keywords

ClinConnect Summary

This clinical trial is exploring how a personalized exercise program, combined with video consultations, can help patients with mitochondrial myopathies. Mitochondrial myopathies are genetic disorders that affect how muscles use energy, leading to symptoms like muscle weakness and fatigue, especially after exercise. The trial aims to see if a mixed training approach—incorporating both endurance and strength exercises—can improve physical abilities like muscle strength and tolerance to activity, without causing any adverse effects.

To be eligible for this trial, participants must be adults over 18 years old with a confirmed diagnosis of mitochondrial myopathy, be able to walk (with or without assistance), and have access to a computer or smartphone for video consultations. Participants will work on a personalized training program at home, with guidance and support from healthcare professionals via video calls. This can help them stay motivated and adjust their exercises as needed. It's important to note that the program is designed to fit into their daily lives, making it practical and accessible.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • patient over 18 years-old,
• • with genetically-confirmed mitochondria myopathy,
• • with mitochondrial DNA mutation,
• • clinically dominant myopathic-like disorders according investigator,
• • able to walk with or without assistance,
• • likely to be followed for at least one year without interruption by video consultation (implying internet connexion with computer and camera or smartophone),
• • having given the written and informed consent and being social security member.
• • For patients in childbearing age, she must have used at least one month if reliable contraception.
• Exclusion criteria:
• • patient wih pathology or comorbidity incompatible with the conduct of the study according the investigator during inclusion visit,
• • patient with physical condition incompatible with training program according investigator during inclusion visit,
• • patient having a physical tiredness and/or myalgia during last week with an intensity of 6 on visual and analog scale,
• • pregnant or nursing patient,
• • patient expecting pregnancy during the course of the study,
• • patient protected by law or under guardianship or curatorship, or not able to participate in a clinical trial under L.1121-16 article of French Public Health Regulations.