Thermotherapy Against Persistent Bacterial LUNG Infections

Launched by CHRONIC OBSTRUCTIVE PULMONARY DISEASE TRIAL NETWORK, DENMARK · Apr 22, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called thermotherapy to see if it can help reduce harmful bacteria in the lungs of people with chronic lung infections. The goal is to find out if spending time in a sauna—where the temperature is very high—can help clear out these bacteria, which are often hard to treat with antibiotics. The study is open to adults aged 18 and older who have had positive tests for specific bacteria in their lung samples at least twice in the last two years, even after antibiotic treatment.

Participants in the study will be asked to use a sauna at least four times a week for six months, with each session lasting at least seven minutes. This trial is currently looking for volunteers, and it's important to know that there are some health conditions that may prevent someone from joining, such as severe allergies or certain mental health issues. Overall, this research could provide new insights into how to treat persistent lung infections more effectively.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • Competent and capable
• • FEV1\>1,0 L
• • Have had a positive culture from sputum or BAL min. 2 times in the last 24 months for bacteria of the species: Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Staphylococcus aureus, Haemophilus influenzae, Achromobacter xylosoxidans, Klebsiella oxytoca or Klebsiella pneumoniae. In addition, min. 1 positive culture after treatment with antibiotics
• • Willing to go to a sauna (min. temperature of 85℃ for at least 7 minutes) four times weekly for six months or avoid going to a sauna for six months
• Exclusion Criteria:
• • Allergy to lidocaine and/or midazolam
• • Contraindications to bronchoscopy
• • Previous severe laryngospasm (intubation requiring)
• • Pregnancy/breastfeeding
• • Severe linguistic problems or inability to give informed consent
• • Severe mental illness that is not controlled with medication. NB: Patients with controlled mental illness can be included and will be asked on an equal footing as others