Exercise Training and Fat Metabolism in Postmenopausal Women

Launched by FLORIDA STATE UNIVERSITY · Apr 22, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how resistance training, which involves lifting weights or using resistance bands, can help improve fat metabolism in postmenopausal women who are obese and at risk of developing type 2 diabetes. Researchers want to see if this type of exercise can help these women manage their weight and reduce the risk of health issues related to fat storage and metabolism.

To be eligible for the trial, participants must be women aged 50 to 70 who are postmenopausal, have a body mass index (BMI) between 30 and 39.9, and show signs of prediabetes. They should not be engaging in regular exercise beyond light activity and must not be smokers or using hormone replacement therapy. If you join the study, you can expect to participate in a structured exercise program focusing on resistance training, while also receiving support and guidance throughout the trial. This research could lead to valuable insights on how exercise can benefit women's health, especially for those facing obesity and prediabetes.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women
• • Postmenopausal (50-75 yrs.)
• • Obese (BMI 30-50 kg/m2)
• • Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
• • Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week)
• • Non-smokers
• • No hormone replacement therapy for at least the past two years.
• Exclusion Criteria:
• • Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week)
• • Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
• • Type 1 or type 2 diabetes
• • Medical problems in which exercise is contraindicated, such as chronic infections
• • History of, or currently presentation with, cancer, cardiovascular or respiratory disease
• • Uncontrolled thyroid dysfunction, liver or renal dysfunction
• • Taking any medication affecting lipid metabolism
• • Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training
• • Smokers and those with diagnosed eating disorders