Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study

Launched by THE AFFILIATED NANJING DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL · Apr 27, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at how different treatments for patients with a condition called autonomous cortisol secretion affect their thinking and brain function. Autonomous cortisol secretion happens when the adrenal glands produce too much cortisol, a hormone that can impact many body functions. The study aims to understand these effects better by using special brain scans and cognitive tests. It will help researchers learn how these treatments might improve patients' mental abilities and overall brain health.

To participate in the study, you should be between 20 and 65 years old, have completed at least six years of education, and be right-handed. Additionally, you need to have adrenal lesions that are 1 cm or larger and either non-functioning adrenal adenomas or autonomous cortisol secretion. If you join the study, you will undergo cognitive function tests and brain scans, and your progress will be monitored over time. This research may provide valuable insights into how treatment can help improve cognitive function in individuals with this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age 20-65 years;
• • ≥ 6 years of education；
• • right-handed;
• • complete entire cognitive function tests;
• • adrenal lesions ≥ 1 cm in diameter;
• • patients with non-functioning adrenal adenomas;
• • patients with autonomous cortisol secretion.
• Exclusion Criteria:
• • \< 6 years of education;
• • age \< 20 years or \> 65 years;
• • maximum diameter of AI \<1cm;
• • active malignancies;
• • with a history of thyroid disease;
• • with a history of acute infection in the last month;
• • central nervous system diseases, including brain trauma, intracranial hemorrhage, acute cerebral infarction, etc;
• • contraindications of MRI examination: such as implantation of metal prosthesis in vivo, claustrophobia, etc;
• • adrenal tuberculosis;
• • suspected or diagnosed adrenocortical carcinoma;
• • unable to complete entire cognitive function tests;
• • current use of steroids or any drugs known to alter steroid synthesis or metabolism in the previous 3 months;
• • clinical Cushing syndrome;
• • Cushing disease;
• • primary hyperaldosteronism;
• • pheochromocytoma;
• • severe impairment of heart, liver, kidney and other organs;
• • pregnant and lactating women