Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · May 2, 2022

Keywords

ClinConnect Summary

The PEAC Trial is a clinical study comparing two different mixtures of medications—propofol and etomidate—used for anesthesia during certain medical procedures called endoscopies. The trial aims to see how these mixtures affect patients' heart function and any side effects that might occur. One mixture uses 25% propofol and 75% etomidate, while the other uses 75% propofol and 25% etomidate.

To participate in this study, you need to be an adult (at least 18 years old) who is scheduled for an endoscopic procedure at Clements University Hospital and have a certain level of health, indicated by a score known as ASA 3 or higher. You will need to have a test showing your heart's pumping ability, called an ejection fraction. However, if you have allergies to the study drugs, can’t provide consent, or are currently pregnant, you won’t be able to join. If you participate, you can expect to receive one of the two medication mixtures and will be monitored for any side effects during your procedure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Adult patients (age ≥18 years old)
• • 2. Having endoscopic procedure at CUH with anesthesia
• • 3. ASA 3 or above
• • 4. Ejection Fraction test result available
• Exclusion Criteria:
• • 1. Known allergies or adverse reactions to study drugs or study drug components or preservatives
• • 2. Patient refusal
• • 3. Clinician refusal
• • 4. Documented cognitive impairments precluding subject ability to consent for themselves unless a surrogate documented legally acceptable decision maker consents for patient participation
• • 5. Prisoner or incarcerated or patients held by law enforcement officials in custody
• • 6. Pregnancy or patient refusal for pregnancy testing or screening (standard UTSW policy and protocol requires pregnancy testing for appropriate patients prior to anesthesia)