Therapeutic Monitoring of Antibiotics in Intensive Care Patients: a Cohort Study PopTDM-ICU

Launched by POITIERS UNIVERSITY HOSPITAL · May 4, 2022

Keywords

ClinConnect Summary

The POP-TDM-ICU study is looking at how we can better use antibiotics to help patients in the Intensive Care Unit (ICU) who are battling severe infections like sepsis or septic shock. The researchers want to understand what factors influence how well these antibiotics work, especially by monitoring the levels of the medication in the body to ensure patients are receiving the right dosage. This study is important because improving antibiotic treatment can reduce the high risk of death associated with these infections.

To participate in this study, patients must be at least 18 years old, currently hospitalized in the ICU, and receiving antibiotics for sepsis or septic shock. It's important that they or their family members agree to take part in the study. Participants will not have to make any changes to their treatment; instead, some extra blood samples will be taken to help researchers gather the information they need. This study is currently not recruiting participants yet, but it aims to provide valuable insights that could lead to better care for critically ill patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient ≥ 18 year-old.
• • Patient hospitalized in intensive care,
• • Patient receiving an antibiotic for sepsis or septic shock
• • Patient or family member who does not object to participating in the study
• Exclusion Criteria:
• • Patient at risk of death, for a cause other than infectious, within 48 hours following the introduction of antibiotic therapy.
• • Patient receiving antibiotic treatment for antibiotic prophylaxis.
• • Patients benefiting from enhanced protection, namely: minors, persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social establishment, adults under legal protection.
• • Pregnant and / or lactating women.