Effect of Breastfeeding on Lipid Profile and Cardiovascular Risk Markers in Women with Familial Hypercholesterolemia

Launched by OSLO UNIVERSITY HOSPITAL · May 4, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how breastfeeding affects cholesterol levels and heart health in women with a genetic condition called familial hypercholesterolemia (FH), which causes high cholesterol. The researchers want to compare the health of women with FH to those without it during and after pregnancy. They will invite women who are pregnant or planning to become pregnant to join the study, regardless of whether they plan to breastfeed or not.

If you are a woman over 18 years old, either with FH or without it, and you are pregnant or planning a pregnancy, you may be eligible to participate. Throughout the study, you will attend several visits where your health, lifestyle, and diet will be monitored, and blood samples will be taken. Additionally, the study will look at how medication for high cholesterol can affect breast milk. It's important to note that there are no specific exclusions, so if you meet the criteria, you can consider joining the trial. This research aims to better understand the impact of breastfeeding on cholesterol and heart health for women with FH.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria for women with FH:
• • 1. age 18 years or older,
• • 2. confirmed diagnosis of FH through genetic testing or clinical assessment based on the Dutch Lipid Clinic Network,
• • 3. singleton pregnancy in the third trimester,
• • 4. a sufficient command of Norwegian, Dutch, Czech or English language.
• Exclusion Criteria for women with FH:
• • Not filling the inclusion criteria.
• Inclusion Criteria for women without FH:
• • 1. age 18 years or older,
• • 2. singleton pregnancy in the third trimester,
• • 3. a sufficient command of Norwegian or English language.
• Exclusion Criteria for women without FH:
• • 1. known pre-pregnancy hypercholesterolemia,
• • 2. a history of ASCVD.