Adaptations of Exercise Energy Metabolism in Response to Weight Loss in Healthy Normal Weight People

Launched by UNIVERSITY HOSPITAL, CLERMONT-FERRAND · May 6, 2022

Keywords

ClinConnect Summary

The NUTRILEX study is looking into how healthy people with normal weight respond to weight loss through dieting and exercise. As more people in this category are trying to lose weight, the study aims to understand the changes that happen in their bodies when they lose weight. Participants will go through two main phases: first, they will complete various exercise sessions, sometimes at their normal weight and other times with their weight simulated to be lower. Then, they will follow a diet to lose about 6% of their body weight, followed by more exercise sessions to see how their bodies react.

To be eligible for this study, participants must have a Body Mass Index (BMI) between 18.5 and 24.9, have had stable body weight for at least six months, and be able to understand the study details and give consent. The study is open to anyone aged 18 and older, regardless of gender. Participants can expect to engage in physical activities, follow a dietary plan, and provide valuable information that could help researchers understand healthy weight loss better. It's important to note that individuals with certain medical conditions, high levels of physical activity, or recent weight loss efforts may not qualify for the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Body mass index (BMI) between 18.5 and 24.9 kg/m²,
• • Subjects abled to understand the information note and abled to sign the consent form,
• • Subjects with stable body weight (variation \< 3% of body weight) until at least 6 months,
• • Subjects subjected to a social security plan.
• Non-Criteria:
• • Have achieved a minimal BMI \< 18.5 or maximal BMI ≥ 25 kg/m² in adult life,
• • Subjects with high levels of physical activity (\> 5 h of exercise per week),
• • Presence of comorbidities or medical conditions that may interfere with study data,
• • Subjects undergoing energy restriction or physical activity weight loss program at the time of inclusion or within the past 6 months,
• • Taking medication that may interfere with study results,
• • Surgery within the last 3 months,
• • Person under guardianship, curatorship, or safeguard of justice; or not subject to a social security plan,
• • Pregnant or breastfeeding women,
• • Refusal to sign the consent form,
• • Person in a period of exclusion from another study,
• • Regular consumption of tobacco or alcohol,
• • Voluntary weight loss in the last 6 months,
• • Present or past eating disorders.