Neural Mechanisms of Response Inhibition Training for OCRD

Launched by UNIVERSITY OF WISCONSIN, MILWAUKEE · May 11, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a new computerized training program called response inhibition training (RIT) to help people with obsessive-compulsive disorder (OCD), trichotillomania (the urge to pull out hair), and skin-picking disorder. Many individuals with these conditions struggle to control their urges, and this trial aims to see if RIT can improve their ability to resist these impulses, which could lead to better management of their symptoms. Participants will be randomly assigned to receive either the RIT or a placebo training that doesn’t have the same therapeutic effect. The study will track changes in symptoms and brain activity over time to see how effective the training is.

To be eligible for this trial, participants must be between 18 and 60 years old and have moderate symptoms of OCD or related disorders. They should have a primary diagnosis of one of these conditions and show difficulty in controlling their responses. However, individuals with certain conditions like severe ADHD or psychotic disorders, as well as those currently undergoing psychotherapy or taking specific medications, may not qualify. Participants can expect to attend 8 to 16 training sessions and will undergo evaluations at the start, after completing the training, and again one month later to assess any changes. This trial is currently recruiting and aims to find new ways to help those struggling with these challenging disorders.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age between 18 and 60
• • moderate level of OCRD symptoms (Yale-Brown Obsessive Compulsive Scale total ≥ 16, Massachusetts General Hospital-Hair pulling Scale total ≥ 12, or Skin Picking Scale-Revised total ≥ 7)
• • a primary diagnosis of OCRD (i.e., OCD, TTM, or SPD)
• • estimated IQ \> 80
• • presence of a RI deficits (SSRT ≥ 215ms).
• Exclusion Criteria:
• • Current substance use disorder
• • Severe ADHD
• • Lifetime diagnosis of psychotic disorder, bipolar disorder, or schizophrenia
• • Current psychotherapy
• • Change in psychotropic medication status within 8 weeks before the study or during the study
• • Use of stimulant medication
• • Active suicidal risk
• • Contraindications for MRI procedures