Endodontic Microsurgery With the Use of L-PRF Block

Launched by UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN · May 12, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment approach for patients with serious dental issues, specifically large periapical lesions, which are infections at the tip of the tooth root. The trial is investigating whether using a special material called leucocyte and platelet-rich fibrin (L-PRF Block) during a type of surgery known as endodontic microsurgery (EMS) can improve how comfortable patients feel after surgery and help their bone heal better.

To participate in this study, patients need to be at least 18 years old and require EMS as the only way to treat their dental problem. They must also have a periapical lesion that is at least 10mm in size. However, certain conditions may prevent someone from joining, such as having recent cancer treatment, specific diseases, or other health issues. If eligible, participants can expect to receive this new treatment and be monitored to see how well it works in terms of comfort and healing after their surgery.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • Provision of Informed Consent
• • Patients from 18 years old
• • Patients in need of an EMS
• • EMS is the only option to cure the periapical lesion
• • A periapical lesion that has a diameter of 10mm or more in sagittal plane, frontal plane or axial plane when measured on CBCT
• • Exclusion Criteria
• • Unlikely to be able to comply with the study procedures, as judged by the investigator
• • Orthograde endodontic (re)treatment is indicated
• • Known or suspected current malignancy
• • History of chemotherapy within 5 years prior to study
• • History of radiation in the head and neck region
• • History of other metabolic bone diseases
• • History of bleeding disorders
• • HIV disease
• • Hepatitis B or C
• • Systemic disease (osteoporosis, diabetes...)