Effect on Bronchodilation Response and Ventilation Heterogeneity of Different Inhalation Volumes in COPD

Launched by UNIVERSITY OF MILAN · May 15, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at how different ways of inhaling medication can affect its effectiveness for people with chronic obstructive pulmonary disease (COPD). Specifically, it will explore whether inhaling a bronchodilator (a type of medicine that helps open the airways) at a certain lung volume makes the medication work better. The researchers believe that inhaling the medication at a fuller lung capacity might help distribute the medicine more evenly in the lungs, leading to better breathing.

To participate in this study, you need to be over 40 years old, have a history of smoking for at least 10 years, and have a specific level of lung function that indicates a need for bronchodilator testing. However, if you have asthma, other serious lung diseases, or certain health conditions, you may not be eligible. If you join the study, you'll undergo tests to see how well the bronchodilator works at different inhalation techniques, which might make it easier for future patients to use this type of treatment effectively.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age above 40 years old;
• • history of smoking equal or above 10 PKYs;
• • VEMS after bronchodilatation ≤ 70%,
• • medical Necessity to perform a bronchodilatation test.
• Exclusion Criteria:
• • history of bronchial asthma or other chronic respiratory diseases such as pulmonary fibrosis;
• • uncontrolled cardiovascular diseases at the time of the visit;
• • current pregnancy;
• • incapacity to execute lung function tests for cognitive impairment, substance abuse or claustrophobia;
• • known hypersensitivity or intolerance to salbutamol.