Biomarkers in Autoimmune Diseases, Vasculitis and Auto Inflammatory Diseases

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · May 16, 2022

Keywords

ClinConnect Summary

This clinical trial is focused on understanding autoimmune diseases, which are conditions where the body's immune system mistakenly attacks its own tissues. The researchers aim to identify specific markers—called cytokines and lymphocyte biomarkers—in patients with autoimmune diseases, systemic vasculitis, and autoinflammatory diseases. By analyzing blood and tissue samples from participants, the goal is to find ways to personalize treatment and follow-up care for each patient based on their unique disease activity.

To be eligible for the trial, participants must be at least 18 years old and have a diagnosed autoimmune disease, such as lupus, vasculitis, or certain autoinflammatory diseases, among others. The study is currently recruiting participants and aims to improve understanding of these complex conditions, which could lead to better management options in the future. If you join the study, you’ll provide biological samples as part of your regular care, and your participation could help advance medical knowledge in this important area.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients of 18 years of age or older
• * Patients with autoimmune systemic disease, systemic vasculitis or autoinflammatory disease, defined by the international criteria in force for each pathology, among the following:
• • Connectivities: lupus, Sjögren syndrome, antiphospholipid syndrome, mixed connectivity and Sharp syndrome, scleroderma, myositis
• • Vasculitis of large, small and medium vessels: giant cell arteritis, Takayasu arteritis, Behçet disease, ANCA vasculitis, cryoglobulinemic vasculitis, IgA vasculitis (rheumatoid purpura)
• • Buerger's disease (obliterating thromboangitis)
• • Granulomatosis and sarcoidosis
• • Uveitis
• • Monogenic and polygenic autoinflammatory diseases: family Mediterranean fever, TRAPS, CAPS, chronic atrophic polychondritis, pericarditis
• • Recurrent fevers and unexplained inflammatory syndromes
• • Inflammatory amyloidosis
• • Patients affiliated to French social security
• Exclusion Criteria:
• * Vulnerable populations:
• • Persons deprived of liberty by judicial or administrative decision;
• • Persons receiving psychiatric care without their consent;
• • Adult subject to a legal protection measure (guardianship, curatorship);
• • Persons unable to give their consent.