Adaptive Optics Retinal Imaging in Inherited and Acquired Retinal Disorders

Launched by THE HOSPITAL FOR SICK CHILDREN · May 18, 2022

Keywords

ClinConnect Summary

This clinical trial is designed to study various eye conditions, specifically focusing on inherited and acquired retinal disorders. Researchers are using a special imaging technology called adaptive optics (AO) to get a clearer view of different parts of the retina, which is the light-sensitive layer at the back of the eye. By looking at these retinal structures in detail, the study aims to see how they change from normal in patients with retinal disorders. The trial will also track how these changes respond to different treatments, helping doctors understand how effective various therapies are.

To participate in this study, individuals must be between the ages of 5 and 70 and have a diagnosed retinal disorder. There’s also a control group for those with normal eye health. Participants can expect to undergo non-invasive imaging tests to assess their retinal condition. However, there are some criteria that could prevent someone from joining, such as certain eye movements or conditions that could interfere with the imaging. Overall, this study aims to improve how we diagnose and treat retinal disorders by using advanced imaging techniques.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Consent provided
• • 2. Aged 5 - 70 years
• • 3. Diagnosed with well documented retinal disorder
• Control group Inclusion Criteria:
• • 1. Subjects aged 5 years - 70 years with normal eye examination.
• • 2. Patients with strabismus and otherwise normal visual acuity and eye examination
• • 3. Patients with unilateral eye diseases such as cataract, with a normal eye exam in the fellow eye.
• Exclusion Criteria:
• • 1. Inability of the subject to maintain a stable position while seated
• • 2. Uncontrolled nystagmus, trembling or movements of the eyes or the head
• • 3. Presence of cataract or any opacity in the front of the eye that obscures retinal imaging
• • 4. Any general disease such neurological disease which could affect vision and the retina.
• • 5. History of previous uveitis, glaucoma, previous intra-ocular surgery or photodynamic therapy
• • 6. High refractive errors (\> +15D or \< -15D) that cannot be corrected by the adaptive optics system.
• • 7. Patients who have a history of photosensitivity or take any medicine that cause photosensitivity as a side effect
• • 8. Patients who are aphakic after cataract surgery