Delineating Between Pathophysiologic Phenotypes of Hypoxic Ischemic Brain Injury After Cardiac Arrest

Launched by UNIVERSITY OF BRITISH COLUMBIA · May 23, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how the brain gets oxygen after a person has had a cardiac arrest, which is when the heart stops beating. Researchers have found that some patients struggle to get enough oxygen into their brains even when more oxygen is delivered through the blood. This trial aims to identify patients who have normal versus abnormal oxygen transport in their brains and to understand why some people have these issues. Understanding these differences could help improve care for patients after a cardiac arrest.

To participate in the trial, individuals must be over 19 years old, have experienced a cardiac arrest with a Glasgow Coma Scale score of 8 or lower (which measures consciousness), and have had invasive monitoring set up within 72 hours of the cardiac arrest. Additionally, their cardiac arrest must have lasted longer than 10 minutes. People with certain medical conditions or those currently taking specific medications may not be eligible. Participants can expect a series of evaluations to assess how well their brains are receiving oxygen, which could help shape future treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1) Greater than 19 years old post cardiac arrest with a Glasgow Coma Scale of 8 or less
• • 2) Invasive monitoring implemented within 72 hours of cardiac arrest
• • 3) Duration of cardiac arrest greater than 10 minutes.
• Exclusion Criteria:
• • 1) Coagulopathy (INR \> 1.5, PTT \> 40, Platelets \< 100x106 per microliter)
• • 2) Current or anticipated use of anticoagulant or antiplatelet medication
• • 3) Target temperature under 35oC; 4) history of severe TBI, intracranial hemorrhage or stroke.