Electroclinical Correlation of Anxiety

Launched by UNIVERSITY HOSPITAL, BORDEAUX · May 23, 2022

Keywords

ClinConnect Summary

This clinical trial, titled "Electroclinical Correlation of Anxiety," is studying how anxiety disorders relate to brain activity in patients with drug-resistant epilepsy. Anxiety disorders are common and can greatly affect a person's life, but many current treatments don’t help everyone. The researchers aim to better understand the brain mechanisms behind anxiety, which could lead to improved treatments.

To participate, individuals must be between 18 and 65 years old and have drug-resistant epilepsy. They should also be undergoing a specific brain assessment called stereo-EEG and either have a diagnosis of generalized anxiety disorder or not have it at all. Participants will need to provide written consent to be part of the study. Those who are pregnant, unable to provide consent, or have other severe mental health issues will not be eligible. If you join the trial, you can expect to undergo tests that will help researchers learn more about the connection between epilepsy and anxiety, potentially paving the way for better treatment options in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Man or woman
• • Aged 18 to 65;
• • With drug-resistant epilepsy
• • Benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG
• • Meeting the DSM-5 diagnostic criteria for generalized anxiety disorder ("pathological" population) or not meeting the DSM-5 diagnostic criteria for generalized anxiety disorder ("control" population)
• • WAIS IV full scale IQ \> 75 or IAG \> 81
• • Affiliate or beneficiary of a social security scheme
• • Giving free, informed consent in writing and signed by the participant and the investigator
• Exclusion Criteria:
• • Being unable to give personal consent
• • Be subject to a measure of legal protection (curatorship, guardianship) or placed under judicial protection;
• • Suffer from a chronic delusional disorder (eg: schizophrenia);
• • Have a moderate or high risk of suicide assessed using the corresponding section of the structured psychiatric interview called "Mini International Neuropsychiatric Interview" (M.I.N.I. 7.0) or a score \> 2 on item 10 of the MADRS, assessing suicidal risk;
• • Being pregnant or breastfeeding
• • Have severe and / or decompensated somatic illness other than drug-resistant epilepsy