Effect of Transcranial Magnetic Stimulation on Visual Functions of Adult Amblyopia: a Preliminary Study

Launched by NATIONAL TAIWAN UNIVERSITY HOSPITAL · May 25, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating a potential new treatment for adults with amblyopia, commonly known as “lazy eye.” Amblyopia affects about 3% of adults and causes poor vision in one or both eyes, often due to issues that occurred during childhood, like differences in how the eyes focus or misalignment. The researchers are looking at a non-invasive brain stimulation technique called theta burst stimulation (TBS) to see if it can improve visual functions in adults with this condition. Since there are currently no effective treatments for adult amblyopia, this study could offer new hope.

To participate in the trial, you need to be an adult aged between 20 and 50 years with a noticeable difference in vision between your two eyes. You'll undergo TBS treatment, which is quick and painless, and the researchers will check your vision shortly after the treatment and again two weeks later to see how well it worked. Certain health conditions, like a history of seizures or serious heart problems, may prevent you from joining the study. This trial aims to find the best way to use TBS for improving vision in adults with amblyopia, making it an important step in exploring new treatment options.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Adult amblyopia participants, aged 20-50 years old.
• • 2. Based on inclusion criteria, there was a minimum of 2 lines difference in BCVA between the 2 eyes.
• • 3. An amblyogenic factor and history of amblyopia treatment was recorded
• Exclusion Criteria:
• • 1. Unstable vital sign
• • 2. History of brain injury and/or head trauma
• • 3. Neurological and psychiatric disease
• • 4. Seizures or family history of seizure
• • 5. Pregnancy
• • 6. Uncontrolled migraine or the presence of metallic implants or shunt in the head or torso
• • 7. Wide region of ischemic cicatrix, multiple sclerosis, taking tricycle antidepressants,
• • 8. Analgesics or any drugs may decrease the threshold for inducing seizure
• • 9. Experienced sleep disorders during the rTMS treatment
• • 10. Severe alcoholism or taking seizure drugs
• • 11. Severe heart diseases or uncontrollable migraine caused by high intracranial pressure