Metagenomic Study in Parapneumonic Effusion

Launched by CHINESE UNIVERSITY OF HONG KONG · May 23, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating a condition called parapneumonic effusion, which involves fluid build-up in the space around the lungs due to infections. The researchers want to find out how well a new method called next-generation sequencing can identify both known and unknown bacteria that cause these infections, comparing it to traditional lab tests. If you're hospitalized for a suspected pleural infection and are 18 years or older, you might be eligible to participate in this study.

Participants will have pleural fluid collected for testing and will be followed for six months to see the outcomes of their infections. It's important to know that the usual medical care you receive won’t change if you join the trial. The study aims to better understand the types of bacteria involved in these infections and how they affect treatment, which could lead to improved care for future patients. If you have questions or want to know more about whether you qualify, please talk to your healthcare provider.

Gender

ALL

Eligibility criteria

• • Study group (patients with parapneumonic effusion)
• Inclusion Criteria:
• • Patients hospitalized for suspected pleural infection, irrespective of community-acquired or hospital-acquired in nature
• • Pleural tapping will be performed for pleural fluid analysis
• • Chinese ethnicity
• • Aged 18 years old or above
• Exclusion Criteria:
• • Use of antibiotics for more than 24 hours for the current episode of infection
• • On long-term local or systemic antibiotics
• • Tuberculous pleuritis
• • Pregnant or lactating women
• • Failed to obtain informed consent due to patient's refusal or cognitive impairment
• • Control group (patients with effusions but not parapneumonic in nature)
• Inclusion Criteria:
• • Pleural effusion is not related to any infection including pneumonia (e.g. malignancy, fluid overload)
• • Pleural tapping will be performed for pleural fluid analysis
• • Chinese ethnicity
• • Aged 18 years old or above
• Exclusion Criteria:
• • The use of systemic (including oral and intravenous) and inhaled antibiotics in the past 1 month
• • On long-term local or systemic antibiotics
• • Tuberculous pleuritis
• • Pregnant or lactating women
• • Failed to obtain informed consent due to patient's refusal or cognitive impairment