Incidence of Major Complication in Case of Thoracic Aortic Aneurysm

Launched by UNIVERSITY HOSPITAL, LILLE · May 24, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the risk of major complications in patients with a thoracic aortic aneurysm, which is a bulging area in the aorta located in the chest. The trial aims to understand how often serious issues occur in patients with small to moderate-sized aneurysms and to identify factors that might affect how these aneurysms develop over time. Researchers believe that conditions like high blood pressure and sleep disorders could increase the risk of aneurysm enlargement.

To participate in this study, individuals must have a documented thoracic aortic aneurysm larger than 40 mm and be willing to commit to a 5-year follow-up. However, those with certain health conditions, such as severe high blood pressure or a history of specific heart diseases, will not be eligible. Participants will undergo regular check-ups and imaging tests throughout the study to monitor their condition. This trial is currently recruiting participants and welcomes individuals of all genders between the ages of 16 to 29.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Documentation of an aortic root aneurysm \> 40 mm
• • Agreement to participate to a longitudinal study and available for a 5 years follow-up
• Exclusion Criteria:
• • Presence of comorbidities or pathology with a prognosis of less than 1 year
• • Personal or family history of genetically documented elastic tissue disease or patient meeting the GAND clinical criteria suggestive of Marfan disease
• • High-grade mitra-aortic valve disease, even if asymptomatic
• • Unbalanced hypertension ≥ 180/110 mmHg
• • Aneurysm (regardless of thoracic or abdominal location) ≥ 50 mm
• • Aneurysm (regardless of thoracic or abdominal location) with documented progression of more than 5 mm over one year
• • History of aortic surgery or endovascular intervention and history of type B aortic dissection of medical treatment
• • Renal insufficiency on dialysis, or GFR\< 30 ml/mn (CKD-EPI)