Pharmacokinetic Profile of Lidocaine Given as a Weight-based Infusion for Postoperative Surgical Pain Control

Launched by UNIVERSITY OF ALBERTA · May 29, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how a medication called lidocaine can help control pain after surgery. Lidocaine will be given through an IV (a small tube inserted into a vein) based on the patient's weight. The researchers want to understand how lidocaine levels in the blood change over time in patients who have had major surgeries, such as those in ear, nose, throat, urology, or general surgery. The study will include 40 participants between the ages of 18 to 40 or over 75 years old, who are generally healthy (classified as ASA class 1-3) and are scheduled for elective surgery.

If you or a family member qualifies for this trial, you can expect to receive a specific dose of lidocaine during and after surgery to help manage pain. You will also be monitored closely to see how the medication works in your body. It's important to note that individuals with certain health issues, like severe heart problems or a history of allergic reactions to lidocaine, cannot participate. This trial is taking place at the University of Alberta Hospital and aims to improve pain management for future surgical patients.

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Eligibility criteria

• Inclusion Criteria:
• • ASA class 1-3. Age 18-40 or \>75. - Scheduled for elective major surgery at the University of Alberta Hospital in which lidocaine infusion would be a good option as part of standard multimodal analgesia care
• Exclusion Criteria:
• • Contraindication / History of hypersensitivity to lidocaine or amide local anesthetics
• • Inability to give informed consent (illiteracy, \<7th grade education)
• • NYHA class III-IV heart disease
• • Planned epidural or regional anesthesia technique requiring local anesthetic