The Poor Responders Study

Launched by IMPERIAL COLLEGE LONDON · May 30, 2022

Keywords

ClinConnect Summary

The Poor Responders Study is investigating why some people do not lose as much weight as expected after bariatric surgery, which is a common treatment for obesity and type 2 diabetes. While most patients see significant weight loss, a small group, known as "poor responders," either lose less weight or regain weight after initially losing it. This study aims to identify the physiological factors that differentiate these poor responders from those who do well after surgery. Researchers will look at how full these patients feel after eating, how many calories they burn, and certain genetic markers that may contribute to their weight challenges.

To participate in this study, you should be between 18 and 70 years old and either have had bariatric surgery at least a year ago or be waiting for the surgery at the Imperial Weight Centre. You’ll need to be able to give informed consent and have no significant health issues that could interfere with the study. Participants can expect to undergo assessments that will help researchers understand their body's responses to food and hormones, which may help predict how well they will do after surgery. If you decide to join, your contributions could lead to better outcomes for future patients facing similar challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged 18 -70 years.
• • Male or female.
• • Previous bariatric surgery for obesity and/or diabetes (studies 1 and 2).
• • ≥1 year interval after bariatric surgery (studies 1 and 2).
• • Awaiting bariatric surgery at the Imperial Weight Centre (study 3)
• • Able to give informed consent.
• Exclusion Criteria:
• • History of any medical, psychological or other condition, or use of any medications, including over-the-counter products, which, in the opinion of the investigators, would either interfere with the study or potentially cause harm to the volunteer.
• • Without access at home to a telephone or other factor likely to interfere with ability to participate reliably in the study.
• • Pregnancy or breastfeeding.
• • Unable to maintain adequate contraception for the duration of the study and for one month afterwards.
• • History of hypersensitivity to any of the components of the subcutaneous infusions.
• • Donated blood during the preceding 3 months or intention to do so before the end of the study.
• • Any other co-morbidity that would compromise the validity of the study or the safety of the participant such as heart failure or clinically apparent cardiovascular disease.
• • Anatomical or endocrinological pathology causing poor weight loss or weight regain
• • Uncontrolled hypertension (systolic blood pressure of 160 mmHg or above and/or diastolic blood pressure of 100 mmHg or above)
• • Participation in a research study within the last two months.
• • Unable to speak English (this is relevant to answering the psychological questionnaires)