Hybrid AbLaTion of Atrial Fibrillation

Launched by ST. GEORGE'S HOSPITAL, LONDON · Jun 6, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at a new treatment approach called hybrid ablation for patients with persistent atrial fibrillation (AF), which is a type of irregular heartbeat that lasts a long time. The trial compares this new method to the standard catheter ablation, which is a common procedure used to treat AF. The goal is to see if the hybrid approach is more effective in helping patients feel better and reducing their symptoms.

To participate in this study, you need to be at least 18 years old and have persistent or long-standing atrial fibrillation. You should also have a dilated left atrium, which is an enlarged heart chamber. However, if you've had certain heart surgeries or conditions that affect your ability to participate safely, you may not be eligible. If you join the trial, you can expect to receive either the hybrid treatment or the standard procedure, and the team will monitor your progress closely. This trial is currently recruiting participants of all genders, and it’s a great opportunity to contribute to research that could improve treatments for AF.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • Persistent or Long-standing Persistent AF
• • Dilated left atrium
• • Suitable for either procedure
• Exclusion Criteria:
• • Unable to provide written consent
• • Previous open-heart surgery
• • Active infection, oesophageal ulcer stricture or oesophageal varices
• • Prior catheter ablation of atrial fibrillation (prior ablation for atrial flutter / supraventricular tachycardia or ventricular arrhythmia acceptable)
• • Contraindication to anticoagulation, or active thrombus in left atrium despite therapeutic anticoagulation
• • Severe valvular heart disease
• • Unstable coronary artery disease
• • Uncontrolled ventricular arrhythmia
• • Heart attack or stroke within the last 90 days
• • Pregnant, breast-feeding, or women of childbearing age who plan to get pregnant within six months
• • Severe concomitant condition or presence of an implanted device that would preclude the patient from undergoing trial procedures