Evolutive and Functional Bases of Menstruation in Women - 2

Launched by INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, FRANCE · Jun 7, 2022

Keywords

ClinConnect Summary

This clinical trial, titled "Evolutive and Functional Bases of Menstruation in Women - 2," is studying menstruation and how it has developed in women and other primates. The researchers want to understand the changes in cells and genes that occur in the uterine lining during the menstrual cycle, specifically during the secretive phase. To do this, they will collect tissue samples from women who are having surgery for non-cancerous conditions, like fibroids or polyps, and compare these samples to those from other primates. The goal is to identify specific genes that may play a role in menstruation, which could help improve medical treatments in the future.

To participate in this study, women need to be between 18 and 50 years old, currently menstruating, and scheduled for certain types of surgery within days 21 to 25 of their menstrual cycle. They also need to provide written consent and be covered by social security. However, there are some exclusions, such as women who are pregnant, have certain health conditions, or have used specific contraceptive methods recently. If eligible, participants can expect to contribute to important research that seeks to better understand the biological processes of menstruation.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Be between 18 and 50 years old.
• • Have mensturation at the time of their participation
• • Have given their written consent
• • Have an indication for surgery of hysteroscopy for removal of a polyp and/or fibroid and/or endometrial, endometrialctomy for presumed benign pathology and/or management of a uterine malformation, scheduled between days 21 and 25 of their menstrual cycle
• • Covered by social security
• Exclusion Criteria:
• • Using an intrauterine device contraceptive method during the study or within the previous three months
• • To be Pregnant at the time of collection
• • Have been pregnant in the three months prior to collection
• • Have had amenorrhoea in the three months prior to collection
• • Have received hormonal treatment within the three months prior to collection
• • Have participated in a clinical study within 3 months prior to collection
• • Have a personal history of breast, ovarian, body or cervical cancer
• • Have a diagnosis of endometriosis
• • Have a diagnosis of adenomyosis
• • Have a diagnosis of Lynch syndrome
• • Undergoing hysteroscopy for a condition other than those listed in the inclusion criteria
• • Women who have not given written consent
• • Women who are breastfeeding
• • Women with a body mass index (BMI) of less than 18.5 or more than 30