Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).

Launched by OHIO STATE UNIVERSITY · Jun 7, 2022

Keywords

ClinConnect Summary

The OXY-BAL clinical trial is studying how certain substances, called oxidized lipids, behave in critically ill patients who are on mechanical ventilation and receiving extra oxygen. The researchers want to understand how these substances change when patients are given high levels of oxygen for at least 90 minutes. To do this, they will collect samples from the patients' lungs on two separate occasions, 24 hours apart, and analyze them using advanced technology.

To participate in this trial, individuals must be adults aged 18 or older who are expected to need mechanical ventilation in an Intensive Care Unit for at least 48 hours. However, those who only require mechanical ventilation for certain procedures, have chronic respiratory issues, or are taking specific medications may not be eligible. Participants can expect to have their lung samples taken and studied, which will help researchers learn more about the effects of oxygen in critically ill patients. This trial is currently recruiting participants, and everyone's safety and well-being will be prioritized throughout the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • Adults age =\> 18 and needing Mechanical ventilation in Intensive Care unit expected atleast for 48 hours
• Exclusion Criteria:
• • 1.Mechanical ventilation, only needed for performing procedures- bronchoscopy, esophagogastroduodenoscopy, colonoscopy, or others
• • 2)Chronic respiratory failure prior to admission;
• • 3)Hemoptysis or diffuse alveolar hemorrhage
• • 4)Medication use such as N acetyl cysteine; aspirin, fish oil supplements.
• • 5)Primary team prohibits bronchoscopy for a specific clinical indication or safety;