Sleep, Obesity and Mental Disease - Biological Markers for the Evaluation of Circadian Rhythmicity

Launched by ESBJERG HOSPITAL - UNIVERSITY HOSPITAL OF SOUTHERN DENMARK · Jun 7, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at how sleep patterns, obesity, and mental health conditions like bipolar disorder and schizophrenia are connected. Researchers want to understand how disruptions in our body's natural clock (circadian rhythms) may affect people who are obese and have these mental health issues. The study will involve different groups of participants, including those with obesity and schizophrenia, those with obesity and bipolar disorder, individuals with obesity but no mental health problems, and healthy individuals with a normal weight.

To take part in the study, participants should either have a body mass index (BMI) over 30 and a diagnosis of schizophrenia or bipolar disorder, or have a normal weight with no psychiatric conditions. Participants will visit the clinic twice, complete questionnaires, and undergo physical tests. They will also collect samples from their hair and saliva at home, and wear devices that track their activity and blood sugar levels for a week. This research hopes to shed light on the connections between these conditions, which could lead to better treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Fulfilling the criteria for one of the four study groups:
• • People with BMI \> 30 kg/m2 and schizophrenia spectrum disorder (N=22)
• • People with BMI \> 30 kg/m2 and bipolar disorder spectrum disorder (N=22)
• • People with BMI \> 30 kg/m2 without psychiatric disease or sleep disorders (N=22)
• • People with BMI 18.5 - 25kg/m2 and no psychiatric disease or sleep disorders (N=20)
• Exclusion Criteria:
• • Participants taking oral supplements of melatonin are excluded if pausing is deemed inappropriate.