Metabolomic Approach During Exercise Testing in Myalgia Induced by eXercise

Launched by UNIVERSITY HOSPITAL, CLERMONT-FERRAND · Jun 9, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how the body’s metabolism responds during exercise in patients who may have metabolic myopathy, a condition that affects how muscles produce energy. People with this condition often experience muscle pain, cramps, and fatigue during or after physical activity, and it can be challenging to diagnose. The researchers want to compare blood and urine samples from these patients before and after exercise to see if they can identify specific changes that might help in diagnosing this condition more effectively.

To participate in this trial, you need to be at least 15 years old and have symptoms like muscle cramps or unexplained fatigue during exercise. Healthy volunteers aged 18 to 50 who do not have chronic illnesses and meet certain lifestyle criteria can also join. During the trial, participants will perform exercise tests while researchers monitor their metabolic responses. This study aims to improve our understanding of metabolic myopathy and may lead to better diagnostic methods for this condition in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• For patients:
• * Patient, male or female, adult or minor aged 15 years or more, referred to the Sports Medicine Department of the Clermont-Ferrand University Hospital for metabolic exploration during exercise, as part of the diagnostic work-up for one of the following clinical contexts:
• • Suspicion of metabolic myopathy
• • Cramps, contractures or myalgias during or after exercise
• • Exercise intolerance/fatigability without obvious cause (cardiac and/or respiratory etiology in particular)
• • Episode of malignant hyperthermia or rhabdomyolysis during exercise
• • Unexplained elevation of CPK
• For healthy subjects:
• • Major subject, male or female, 18 to 50 years old.
• • No chronic pathology
• • No treatment (background or at the time of the examination)
• • Non-smoker
• • No/little alcohol consumption (\<5 glasses/week), no consumption in the 48 hours before the stress test
• • Non/little athletic (\<2h of strenuous physical activity/week), no physical activity the day before and the day of (pre- and post-test)
• For all participants:
• • Able to give informed consent to participate in the research
• • For minor patients, consent from the holders of parental authority
• • Affiliation to the French Social Security system
• Exclusion Criteria:
• For healthy subjects:
• • Refusal of registration in the national file of volunteers for research involving the human person.
• • Subject in a period of exclusion from a previous study or having received a total amount of compensation greater than 4500 euros over the 12 months preceding the start of the trial (after verification in the File of Volunteers for Research Involving the Human Person).
• For all participants:
• • Contraindications to an exercise test on a cycloergometer, mainly cardiorespiratory (ATS/ACCP statement on cardiopulmonary exercise testing. Am J Respi Care Med. 2003;167:211-77.)
• • Pregnant women (a pregnancy test will be performed on all participants of childbearing age on the day the exercise tests are performed) and nursing mothers.
• • Refusal to sign the consent form.
• • Patients under guardianship, curatorship, deprived of liberty or safeguard of justice.