Urine HPV Testing for Cervical Cancer Screening Among Women Living With HIV in South Africa

Launched by UNC LINEBERGER COMPREHENSIVE CANCER CENTER · Jun 7, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the use of urine samples to help screen for cervical cancer in women living with HIV in South Africa. Cervical cancer can develop after an infection with the human papillomavirus (HPV), which can lead to changes in the cells of the cervix. The researchers want to see if testing urine for HPV can be a reliable way to find out if women are at risk for cervical cancer, especially since this method hasn't been widely tested in low- and middle-income countries.

To participate in this study, women must be at least 25 years old and confirmed to be living with HIV. They should also be able to give written consent to take part. Women who are pregnant, have been screened for cervical cancer in the past year, or have certain other health issues may not be eligible. Participants will provide urine samples and may undergo additional testing as part of the study. This research could help improve cervical cancer screening for women living with HIV and ultimately lead to better health outcomes.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • In order to participate in this study a subject must meet all of the eligibility criteria outlined below.
• • 1. Confirmed HIV-1 infection
• • 2. Age 25 years and older.
• • 3. Be willing and able to provide written informed consent.
• Exclusion Criteria:
• • 1. Pregnant or intend to become pregnant within 90 days of enrollment
• • 2. Have been screened for cervical cancer within the preceding year (365 days)
• • 3. Have an active sexually transmitted infection (STI; women may participate once treated)
• • 4. Have a surgically absent cervix
• • 5. Have a history of cervical cancer
• • 6. have been vaccinated against HPV.