Carotid Intraplaque Neovascularization Combined With Stress Echo

Launched by DR. AMER JOHRI · Jun 8, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating a new way to improve the accuracy of stress tests used to diagnose heart disease. Heart attacks and strokes can be caused by a condition called atherosclerosis, where plaque builds up in the blood vessels. Currently, stress tests help doctors assess heart function, but they can sometimes give misleading results. The goal of this study is to combine stress tests with ultrasound scans of the neck to check the type of plaque present, which may help identify patients at greater risk for serious heart issues.

To participate in this trial, individuals must be over 18 years old and have been referred for a stress test to evaluate their heart health. However, those with certain conditions, such as active chest pain or a history of heart surgery, won't be eligible. Participants will be monitored for three years to see how well this combined approach works in predicting heart attacks or other major cardiovascular events. This study involves six sites across Canada and aims to provide better care for people at risk of heart disease by improving testing methods.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Men and women \>18 years;
• • 2. Referred for a clinically indicated SE for assessment of ischemia and risk stratification;
• • 3. Able and willing to give informed consent.
• Exclusion Criteria:
• • 1. Emergency procedure, or active acute coronary syndrome (active chest pain, ischemic electrocardiogram changes, or cardiac enzyme elevation);
• • 2. Referral for viability, pulmonary hypertension, or valve assessment;
• • 3. Referral outside of the normal working hours;
• • 4. History of significant CAD: percutaneous coronary intervention (PCI), coronary artery bypass graft (GABG), or coronary angioplasty;
• • 5. History of stroke or myocardial infarction (MI);
• • 6. Known or documented hypersensitivity or allergy to perflutren (DEFINITY® contrast agent);
• • 7. Known or documented allergy to Polyethylene Glycol (Peg) a component of DEFINITY®;
• • 8. History of carotid surgery (endarterectomy or stenting);
• • 9. Any serious medical condition or complication from the stress test that according to the investigator could interfere with the carotid scan or optimal care;
• • 10. Currently pregnant or breastfeeding;
• • 11. Previous enrolment into the study.