Embolization for Meningioma

Launched by ST. OLAVS HOSPITAL · Jun 8, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called endovascular embolization for patients with meningioma, which is a type of tumor that usually grows on the brain's outer layer. The goal of the trial is to see how effective this method is at reducing bleeding during surgery and improving outcomes for patients with growing or symptomatic meningiomas. Currently, surgery is the main treatment option, but it comes with risks, and there aren’t many other treatment choices available. By exploring embolization, researchers hope to find a safer way to manage these tumors.

To be eligible for this study, participants must be 18 years or older and have a diagnosed meningioma that is growing or causing symptoms. They also need to have a good overall health status, meaning they can carry out normal activities. However, people with certain conditions, like previous treatments for meningioma or specific health issues, may not be able to participate. If someone joins the trial, they can expect close monitoring and assessments to evaluate the treatment's effectiveness. This trial is currently recruiting participants, and it’s an important step towards finding more options for meningioma treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Radiological diagnose of typical intracranial meningioma (homogenous contrast enhancement or dural attachment)
• • Indication for treatment due to growth, symptoms or both
• • Tumor location suggestive of vascular supply via middle meningeal artery branches
• • Age 18 years or older
• • Karnofsky performance status of 90 or better (able to carry on normal activity and work)
• Exclusion Criteria:
• • Informed consent not possible (e.g. language barriers, aphasia, cognitive impaired)
• • Previously treated for meningioma
• • Intraosseous growth
• • Tumor related brain edema
• • Neurofibromatosis type 2
• • Systemic cancer
• • Epilepsy
• • Progressive neurodegenerative disorder (eg. MS, Parkinsons disease)
• • History of psychiatric disorder
• • Unfit for participation for any other reason judged by the physician including patients
• • Contraindications to MRI
• • Allergic to contrast agents
• • Relative contraindications to endovascular treatment judged from CT angiography (tortoise carotid arteries, carotid stenosis, calcified aortic arch, anatomical vascular variants/anomalies suggesting increased risk with endovascular treatment)
• • DSA (Digital subtraction angiography) from carotid artery suggesting that significant vascular supply is from other vessels than the MMA.