Akkermansia and Weight Maintenance

Launched by MAASTRICHT UNIVERSITY MEDICAL CENTER · Jun 9, 2022

Keywords

ClinConnect Summary

RATIONALE This study will examine the influence of specific beneficial gut bacteria in relation to weight maintenance. The worldwide prevalence of obesity, obesity-associated insulin resistance, and type 2 Diabetes Mellitus (T2DM) has grown dramatically over the last couple of decades; in every region of the world, obesity prevalence has more than tripled since 1975. Even though obesity treatment strategies, such as lifestyle interventions (focussed on diet and/or physical activity) and bariatric surgery have improved, there is extensive variability in responses. In the short term, reducing...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • BMI ≥ 28 kg/m2 \< 40 kg/m2
• • Weight stable for at least 3 months (± 2 kg).
• Exclusion Criteria:
• • Type 2 diabetes mellitus (fasting plasma glucose ≥ 7.0 mmol/L)
• • Gastroenterological diseases
• • Surgery on the gastrointestinal tract (ex.Bariatric surgery)
• • Cardiovascular diseases, cancer, liver or kidney malfunction, a disease with a life expectancy of \< 5 years;
• • Alcohol (\>15 standard drinks per week) or drug abuse
• • Excessive nicotine use is defined as \>20 cigarettes per day;
• • Use of prebiotics or probiotics 3 months prior to the start of the study;
• • Intensive exercise training, \> 3 hours a week;
• • Use of any medication influencing glucose or fat metabolism (ex. lipid-lowering-drugs e.g. PPAR γ (peroxisome proliferator-activated receptors) or PPARα (fibrates) agonists), glucose-lowering agents (including all sulfonylureas, biguanides, α-glucosidase inhibitors, thiazolidinediones, repaglinide, nateglinide, and insulin), inflammation (e.g. anti-inflammatory or immunosuppressive drugs) and anti-oxidants);
• • Regular use of laxatives
• • Use of antibiotics in the last 3 months
• • Vegan
• • Lactose intolerance
• • Pregnancy or lactation
• • Concomitant participation in another study