A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

Launched by MEMORIAL SLOAN KETTERING CANCER CENTER · Jun 10, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called stereotactic radiosurgery (SRS) for patients who have been diagnosed with small cell lung cancer that has spread to the brain. The goal is to find out if SRS is an effective way to treat up to 10 brain tumors caused by this type of lung cancer. The trial is currently looking for participants aged 18 and older who have a confirmed diagnosis of small cell lung cancer and meet certain health criteria.

To be eligible for this study, participants must have a specific type of brain scan showing their tumors and should be able to understand and give consent to join the trial. Patients who are pregnant, have had previous radiation treatment for the brain, or have other serious health issues that cannot be treated are not eligible. If you participate, you can expect to receive SRS as part of your treatment, and the study will help researchers learn more about how effective this approach is for managing brain metastases in lung cancer patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Histologic diagnosis of small cell lung cancer
• • Radiographic diagnosis of up to 10 brain metastases on contrast-enhanced MRI
• • Age 18 and above
• • Performance status KPS 60-100/ECOG 0-2
• • Female patients must be of non-reproductive potential or have a negative serum pregnancy test at the time of enrollment
• • The patient or legally authorized representative is able to provide informed consent
• Exclusion Criteria:
• • Unable to undergo contrast-enhanced MRI brain or spine
• • Leptomeningeal disease confirmed on lumbar puncture, MRI brain, or MRI spine
• • Pregnant or lactating women
• • Prior brain-directed radiotherapy
• • Uncontrolled systemic disease without reasonable systemic therapy options felt likely to result in death as observed on CT or PET/CT imaging, no more than 3 months before study enrollment