Combined Exercise and Nutritional Intervention in GI Cancer Patients

Launched by HOSPITAL BEATRIZ ÂNGELO · Jun 13, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how a combination of exercise and nutrition can help patients with pancreatic and gastric cancer during their treatment. The researchers want to see if this approach can reduce inflammation, improve the body’s response to chemotherapy, and help maintain muscle mass, which is important for overall health. They believe that focusing on exercise and diet before surgery could be a valuable opportunity to improve patients' wellbeing during their treatment journey.

To participate in this study, patients must be between 40 and 80 years old, have stage II or III gastric or pancreatic cancer, and be able to start neoadjuvant chemotherapy. This means they should be in relatively good health (with a specific performance status) but have not been very active recently. If eligible, participants will engage in a structured program involving exercise and nutritional support. It's important to note that patients with certain health conditions or those on specific medications may not qualify for this trial. Overall, this study aims to provide new insights into how combining exercise with dietary changes could benefit cancer patients during a critical time in their treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • gastric or pancreatic cancer stage II/III, eligible for neoadjuvant chemotherapy,
• • age higher than 40 years and lower than 80 years,
• • ECOG (Eastern Cooperative Oncology Group) functional status: 0-2,
• • sedentary/low physical activity level.
• Exclusion Criteria:
• • life expectancy less than 12 months at inclusion,
• • chemotherapy regimen other than 5-Fluorouracil, Folinic acid, Oxaliplatin, Docetaxel (FLOT) for gastric and 5-Fluorouracil, Irinotecan and Oxaliplatin (FOLFIRINOX) or gemcitabine for pancreatic cancer,
• • metastatic disease,
• • chronic anti-inflammatory medication use,
• • known inflammatory condition (rheumatoid arthritis, ankylosing spondylitis or chronic active hepatitis)
• • cardiovascular, respiratory or musculoskeletal or joint problems that preclude moderate physical activity.