Impact of Sleep Duration on Immune Balance in Urban Children With Asthma

Launched by RHODE ISLAND HOSPITAL · Jun 13, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how the amount of sleep that urban children with asthma get can affect their immune system and lung health. Researchers want to understand if getting less sleep and then trying to catch up on sleep can change how well these children breathe and how their immune system works. This is important because many children living in cities face challenges that can disrupt both their sleep and asthma management.

To participate in this study, children need to be between 7 and 11 years old and have a diagnosed case of asthma that requires medication. They should also have been getting about 9 to 11 hours of sleep each night recently and have positive allergy test results. Participants will be recruited from certain urban areas in Rhode Island and Massachusetts, and their primary caregiver must speak English. If eligible, children will take part in activities that help researchers assess the impact of sleep on their asthma and overall health. This study aims to find better ways to support children with asthma in managing their condition and improving their sleep.

Gender

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Eligibility criteria

• Inclusion:
• • Children 7-11 years old
• • Has physician-diagnosed asthma, per parent and pediatrician report
• • Meets criteria for current persistent asthma with a current prescription for an asthma controller medicine
• • Obtains 9.0-11.0 h of sleep per 24 h day in the past month
• • Has a positive allergy skin test performed at the clinic visit
• • Resides and attend school in one of the targeted urban areas (Rhode Island: East Providence, North Providence, Providence, Warwick, Cranston, Woonsocket, Central Falls, Pawtucket, Lincoln, Johnston. Massachusetts: Attleboro, North Attleboro, Fall River.
• • Has a primary caregiver who speaks English
• Exclusion:
• • No asthma diagnosis
• • No use of asthma controller medication
• • Severe persistent asthma that is poorly controlled
• • Diagnosis of additional pulmonary disease or medical condition or immune deficiency disorders
• • Use of systemic steroids \<30 days of screening
• • Asthma-related emergency department visit and/or asthma-related hospitalization in past 90 days
• • Marked developmental delay, psychiatric conditions, academic/behavioral problems, learning disabilities
• • Tanner stage 3-5 of pubertal development
• • Diagnosed ADHD; Use of stimulants to treat ADHD
• • An Apnea-Hypoxia Index \>5 (indicator of sleep disordered breathing)