Acetate and Age-associated Arterial Dysfunction

Launched by UNIVERSITY OF COLORADO, DENVER · Jun 14, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a supplement called acetate on improving blood vessel function in older adults, particularly those aged 50 and older. As people age, their blood vessels can become stiffer, increasing the risk of heart disease. The researchers believe that taking acetate for 12 weeks might help make blood vessels work better by reducing stress on them and improving blood flow. This could potentially lower the chances of developing heart-related issues in the future.

To participate in the study, you need to be at least 50 years old, have a low intake of dietary fiber, and not have any serious ongoing health conditions like heart disease or diabetes. If you join, you’ll take the acetate supplement for three months and will be monitored for any side effects or changes in your health. This trial aims to understand how well acetate works and how safe it is, so it could lead to new ways to help older adults maintain better heart health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Able to provide informed consent;
• • Age 50+ years;
• • Serum phosphorus levels \>= 2.5 mg/dl at screening;
• • Habitual dietary fiber intake \<30 g/day for men or \<21 g/day for women, based on Block Fiber Screener conducted at screening;
• • Weight-stable in the 3 months prior to enrollment (self-report);
• • Willing to abstain from dietary supplements for 48 hours and from alcohol, tobacco, and cannabis products for 24 hours before all visits;
• Exclusion Criteria:
• • History of current serious, chronic clinical disease, e.g., cardiovascular disease, diabetes, liver disease, Alzheimer's disease and related dementias, cancer;
• • Major changes in health in the past 3 months, e.g., hospitalizations, major surgeries, significant changes in medications;
• • Currently taking calcium acetate or any other calcium supplementation;
• • Screening FMDba \> 8%;
• • Body mass index \> 40 kg/m\^2 at screening;
• • Regular vigorous/aerobic endurance \>4 bouts/week for \>30 min/bout at a workload of \>6 METS;
• • Any apparent dependence on or abuse of alcohol, tobacco, and cannabis products;
• • Pregnancy, breast-feeding, or plans to become pregnant during the duration of the study;
• • Any finding on the medical history, physical exam, or standard clinical blood labs that, in the opinion of the physician of record, would put the subject at increased risk with calcium supplementation.