Waveform Periodicity Analysis of Complex Fractionated Electrograms in Patients With Persistent Atrial Fibrillation

Launched by BUDDHIST TZU CHI GENERAL HOSPITAL · Jun 21, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a new approach to treating persistent atrial fibrillation (AF), a common heart rhythm problem that can lead to serious health issues. Researchers are examining whether a specific method of analyzing heart signals can help identify areas in the heart that need treatment. The goal is to find the best way to perform catheter ablation, a procedure that aims to restore a normal heart rhythm by targeting abnormal electrical signals. Previous studies have shown mixed results, so this trial is looking for more effective strategies.

To be eligible for this trial, participants must be at least 20 years old and have persistent AF that has not responded to at least one heart medication. They also need to be willing to sign consent forms and be monitored throughout the study. Participants can expect to undergo heart mapping and possibly receive catheter ablation treatment, all while being closely followed by the research team. It's important to note that certain conditions, like having a blood clot in the heart or being pregnant, would exclude someone from participating in this trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients who sign the informed consent forms, and allow to be followed.
• • 2. Symptomatic AF refractory or intolerant to at least one Class 1 or 3 antiarrhythmic medication.
• • 3. Patients with persistent/permanent AF (sustained beyond seven days, or lasting less than seven days but necessitating pharmacologic or electrical cardioversion).
• • 4. Patients with age equal or greater than 20 years old regardless of gender.
• Exclusion Criteria:
• • 1. The presence of a atrial or ventricular thrombus.
• • 2. Patients who are allergic to or unsuitable for use with the contrast media.
• • 3. Pregnant patients or patients who are unavailable to receive X-ray.
• • 4. Patients with renal insufficiency.
• • 5. Patients had autonomic nervous system disorder (e.g. respiratory apnea) or previous catheter ablation in the LA or MAZE procedure.
• • 6. Patients who do not need atrial substrate modification (patients with non-paroxysmal AF respond to PVI in terms of procedural termination of AF).
• • 7. Patients with age less than 20 years old or greater than 90 years old regardless of gender.