Vitamin D and Curcumin Piperine Attenuates Disease Activity and Cytokine Levels in Systemic Lupus Erythematosus Patients

Launched by SAIFUL ANWAR HOSPITAL · Jun 21, 2022

Keywords

ClinConnect Summary

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with a relatively high mortality and morbidity rate, especially in developing countries such as Indonesia. In Indonesia, a previous study demonstrated that almost 71% of SLE patients experience hypovitaminosis D, with serum vitamin D (25(OH)D3) levels less than 30 ng/ml. Several factors contribute to the low vitamin D levels among SLE patients. Less exposure to sunlight or insufficient vitamin D intake contributes to SLE patients' low vitamin D levels. Some other studies also revealed that vitamin D metabolism gene ...

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Eligibility criteria

• Inclusion Criteria:
• • SLE patients referred to the Rheumatology outpatient clinic Saiful Anwar General Hospital, Malang, Indonesia
• • Had an active disease, characterized by the Mexican SLE Disease Activity Index (Mex-SLEDAI) score \>3
• • Had low vitamin D levels (serum vitamin D3 levels \<30 ng/ml)
• Exclusion Criteria:
• • Pregnant or breast-feeding patients
• • Took supplementations containing vitamin D or curcumin in the last three months
• • Had severe liver disorders (AST or ALT levels \>2.5 times of upper normal limit)
• • Had impaired renal function (GFR \< 25 ml/min or oliguria with urine output \< 400 ml/day)
• • Had other autoimmune diseases or severe infections such as tuberculosis, pneumonia, or HIV, history of renal stones, hypercalciuria, intestinal malabsorption
• • Refusal to participate in the study