Evaluation of Ablation Lesions Using Cardiovascular Magnetic Resonance Imaging

Launched by R&D CARDIOLOGIE · Jun 20, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a procedure called catheter ablation, which is used to treat a heart condition known as atrial fibrillation. Atrial fibrillation causes the heart to beat irregularly, and the trial aims to understand how well different types of energy used during ablation—radiofrequency, ultra-low temperature cryo, and pulsed field—create scar tissue in the heart. These scars are important because they help prevent the irregular heartbeats from coming back. The researchers will use a special imaging technique called cardiovascular magnetic resonance imaging (MRI) to look at the characteristics of the scars created by each method. They'll also check how often patients experience a return of arrhythmia (irregular heartbeat) and how it affects their quality of life.

To be eligible for this trial, you must be an adult aged 18 or older and have been diagnosed with atrial fibrillation that is either paroxysmal (comes and goes) or persistent (ongoing). You should also be scheduled for a catheter ablation procedure using one of the energy methods mentioned earlier. However, if you have certain conditions like an allergy to a substance used in MRI, issues that would prevent you from undergoing an MRI, or if you are pregnant or breastfeeding, you may not be able to participate. If you join the trial, you can expect to receive the ablation treatment and then be monitored for how well it works and how it impacts your daily life.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (age ≥18 years old)
• • Paroxysmal or persistent atrial fibrillation, meeting criteria of the 2020 European Society of Cardiology Guidelines for diagnosis and management of atrial fibrillation
• • Patients scheduled to undergo catheter ablation for cardiac arrhythmia using one of the following techniques: Radiofrequency ablation (High power, short duration), Ultra-low temperature cryo ablation, or Pulsed field ablation
• Exclusion Criteria:
• • Known (or suspected) allergic reaction to gadolinium
• • Contraindications for MRI (such as claustrophobia, certain implants, devices, high body mass index).
• • Pregnancy or breastfeeding
• • Prior intervention in the left atrium (ablation or surgery)