Peritumoral Microbubbles and CEUS for SLN Detection and Biopsy in HNSCC

Launched by SUN YAT-SEN MEMORIAL HOSPITAL OF SUN YAT-SEN UNIVERSITY · Jun 26, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at a new way to help identify and biopsy lymph nodes in patients with head and neck squamous cell carcinoma, a type of cancer that affects the mouth and throat. The researchers are testing a method that uses tiny gas-filled bubbles (called microbubbles) along with ultrasound imaging. This technique aims to improve the accuracy of detecting sentinel lymph nodes—those are the first lymph nodes that cancer may spread to—without using radiation. By doing this, the study hopes to reduce unnecessary surgeries on the neck, which can lead to complications.

To be eligible for this trial, participants need to be between 18 and 70 years old, have a confirmed diagnosis of head and neck squamous cell carcinoma, and show no signs of lymph node spread based on imaging tests. Patients should also be planning to have surgery for their cancer. If you decide to participate, you can expect to undergo imaging with microbubbles and ultrasound before your surgery, which will help doctors better understand your condition. This study is currently recruiting participants and aims to provide valuable information that could improve treatment for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged 18-70;
• • Pathological biopsy indicated head and neck squamous cell carcinoma;
• • MR/CT examination indicate no suspected cervical lymph node metastasis;
• • The patient intent to perform primary focal resection and unilateral/bilateral neck dissection at our center;
• • agree to participate in clinical trials and sign informed consent.
• Exclusion Criteria:
• • allergic to microbubbles contrast agents;
• • patients who cannot tolerate surgery;
• • enlarged cervical lymph node in palpation or suspected cervical lymph node metastasis indicated in MR/CT examination;
• • distant metastasis.