Parkinson's Disease: Risk Assessment of Persistent Delirium and Its Management

Launched by NEWCASTLE UNIVERSITY · Jun 24, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating how to better identify and manage persistent delirium in older individuals with Parkinson's disease. Delirium is a sudden change in behavior and thinking that can make someone feel confused or act differently than usual. For older adults with Parkinson's, this condition can last over two weeks and can lead to increased need for support and a higher risk of serious health issues. Researchers aim to create a tool that helps predict who is at risk for persistent delirium and to explore the best ways to support those affected.

To participate in this study, you need to be at least 65 years old and have a confirmed diagnosis of Parkinson's disease. You should have experienced delirium lasting more than 14 days or have had other types of delirium. If you're a caregiver for someone with Parkinson’s who has gone through persistent delirium, you might also be eligible to share your experiences. Participants will be asked to provide information from their medical records and may also take part in interviews to discuss their experiences. This research hopes to improve care for people with Parkinson's and persistent delirium, ultimately enhancing their quality of life.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Inclusion Criteria for People with Parkinson's:
• • 1. Participants must be aged at least 65 years old in 2015.
• • 2. Participants must have a diagnosis of idiopathic Parkinson's disease using Queen's Square Brain Bank criteria (32) diagnosed by a movement disorders expert.
• • 3. Admitted patients must have stayed in hospital \>24 hours for at least one hospital admission.
• • 4. Participants must have had previous admissions/attendance to the hospital between 2015-2019.
• • 5. An appropriate consultee must be available and willing to be involved in this study for potential participants without the mental capacity to consent to the extraction of information from their medical records.
• • 6. For the qualitative study, participants must have the mental capacity to consent and must have been affected by persistent delirium. The participant must be able to understand, write and speak English.
• • Inclusion Criteria for Carers in the Qualitative Study
• • 1. Participants must be aged 18 or over.
• • 2. Participants must have the mental capacity to consent.
• • 3. Participants must have been a primary carer for someone living with Parkinson's, who has had a previous experience of persistent delirium, during 2015-2020.
• • 4. Participants must be able to understand, write and speak English.
• Exclusion Criteria:
• • Exclusion Criteria for People with Parkinson's
• • 1. Aged less than 65 years old in 2015.
• • 2. Diagnosed with drug-induced parkinsonism, vascular parkinsonism, atypical Parkinsonian disorder (e.g. progressive supranuclear palsy, multiple systems atrophy, corticobasal syndrome) or dementia (e.g. dementia with Lewy bodies, vascular dementia, Alzheimer's disease).
• • 3. Potential participants will be excluded from the interview if they cannot communicate verbally or cannot read/write in English.
• 4. The potential participant's medical records are incomplete and no alternate strategies are appropriate to account for the missing data, without introducing significant study bias or inaccuracy in statistical findings. Criteria for when the medical records will be excluded in the analysis will be:
• • 1. There is uncertainty regarding the identity of the medical records. 2. Documentation for the admission of interest is missing to the extent that researchers are unable to extract the relevant data required for the aims of this study.
• • 5) For the qualitative study, potential participants will be excluded if they do not have the mental capacity to consent.
• • 6) Potential participants without a consultee and also do not have the mental capacity to consent to this study.
• • 7) Potential deceased participants will be excluded if there is previous documentation that the person would not have wanted to participate in research studies.
• • Exclusion Criteria for Carers in the Qualitative Study
• • 1. The potential participant is aged less than 18 years old.
• • 2. The potential participant does not have the mental capacity to consent to this study.
• • 3. The potential participant is not the primary carer for someone with Parkinson's and has been affected by persistent delirium, during 2015-2020.
• • 4. The potential participant does not understand, write and/or speak English.
• • 5. The potential participant has a severe speech impairment to the extent that the audio recording of the interview is unintelligible.
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