UK Heart Failure With Preserved Ejection Fraction

Launched by MANCHESTER UNIVERSITY NHS FOUNDATION TRUST · Jun 28, 2022

Keywords

ClinConnect Summary

The UK Heart Failure With Preserved Ejection Fraction (HFpEF) trial is looking to better understand a type of heart failure where the heart can pump blood normally, but people still experience troubling symptoms like breathlessness and swelling. This condition, known as HFpEF, affects many individuals, yet we still don’t fully understand what causes it or how to treat it effectively. The goal of this study is to find out why some people develop HFpEF, improve the ways we diagnose it, discover new treatments, and track the health of participants over several years.

To participate in this study, individuals must be between the ages of 65 and 74 and have received a diagnosis of HFpEF from a qualified heart specialist or nurse. Participants will need to provide written consent and have their natriuretic peptide levels measured, which is a test that helps understand heart function. Unfortunately, those with certain heart conditions or severe heart problems will not be eligible to join. If you or a loved one are interested, this study offers a chance to contribute to important research that could lead to better understanding and treatment options for HFpEF.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Written informed consent
• • 2. Diagnosis of HFpEF by a cardiologist with HF expertise, or a primary care physician with HF expertise, or a heart failure nurse
• • 3. Natriuretic peptide levels measured
• Exclusion Criteria:
• • 1. LV EF \< 40% (at screening or any previous measurement)
• • 2. Known infiltrative cardiomyopathy (e.g., amyloid, sarcoid, lymphoma, endomyocardial fibrosis)
• • 3. Known active myocarditis, constrictive pericarditis, or cardiac tamponade
• • 4. Known genetic hypertrophic cardiomyopathy or obstructive hypertrophic cardiomyopathy
• • 5. Known arrhythmogenic right ventricular cardiomyopathy
• • 6. Known severe primary valvular heart disease
• • 7. Known idiopathic, heritable or drug-induced pulmonary arterial hypertension
• • 8. Heart transplantation or ventricular assist device
• • 9. Complex congenital heart disease