TARGETed Therapy Drug MONITOring in DIGestive Oncology

Launched by UNICANCER · Jul 1, 2022

Keywords

ClinConnect Summary

The TARGETed Therapy Drug MONITOring in DIGestive Oncology trial is researching how to better manage and adjust doses of specific cancer medications for patients with advanced digestive cancers, such as metastatic colorectal cancer and liver cancer. The goal is to find out the best dosage for each patient, which may help improve treatment outcomes. This study is currently recruiting participants who are at least 18 years old and have been diagnosed with advanced digestive cancer that requires treatment. Participants must be in a stable condition and have a life expectancy of more than three months.

If you decide to participate, you will receive one of the targeted therapies and will have regular check-ups to monitor your health and the effectiveness of the treatment. It's important to know that you cannot be on other cancer treatments at the same time, and some health conditions may prevent you from joining the trial. Before joining, you'll need to give your written consent, and if you have questions or concerns, you can always ask the research team for more information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patient aged 18 years or over
• 2. Advanced digestive cancer (histologically confirmed or confirmed by imaging for HCC) for which a standard treatment (according to each drug SmPC and as per standard of care) planned with:
• • Regorafenib for GIST, mCRC, and HCC,
• • Everolimus for gepNET,
• • Sunitinib for pNET or GIST,
• • Cabozantinib for HCC,
• • Encorafenib - cetuximab for mCRC
• • 3. Life expectancy of greater than 3 months - at the discretion of the investigator
• • 4. Measurable disease according to tumor evaluation criteria as per local practice (Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1, etc.)
• • 5. Patients must be affiliated to a Social Security System (or equivalent)
• • 6. Patient must have signed a written informed consent form prior to any trial specific procedures. When the patient is physically unable to give their written consent, a trusted person of their choice, independent from the investigator or the sponsor, can confirm in writing the patient's consent.
• Exclusion Criteria:
• • 1. Other concomitant anticancer systemic treatment (chronic chemotherapy, antitumor hormone therapy or immunotherapy) than the one studied
• • 2. Unresolved toxicity higher than NCI-CTCAE v5.0 Grade 1 attributed to any prior therapy/procedure excluding alopecia and peripheral neuropathy
• • 3. Prior treatment with the same MKI molecule(s) planned to be given in the cohort. If different MKI molecules (from the one(s) planned in the study) have been previously taken, a wash out period of 2 weeks before treatment should be observed.
• • 4. Other invasive malignancies either currently active or active in the last 3 years, except adequately treated in situ carcinoma of the cervix and basal or squamous cell carcinoma of the skin
• • 5. Any condition that may jeopardize patient participation in the study as well as non contraception for male and female with child-bearing potential, pregnancy or breast feeding.
• • 6. Patient unwilling or unable to comply with the medical follow-up required by the standard treatment taken (including PK sampling during treatment phase and vital status collection during follow-up phase) because of psychosocial, familial, social or geographical reasons
• • 7. Participation in another clinical study with an investigational medicinal product during the last 30 days prior to inclusion and during the present study (except if patient is included in the control arm, with placebo or with a product which have a marketed authorisation, used as per the SmPC for the given indication)
• • 8. Patient deprived of their liberty or under protective custody or guardianship