Oral Health and Wilson's Disease: SOMAWI

Launched by FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD · Jun 29, 2022

Keywords

ClinConnect Summary

The SOMAWI clinical trial is exploring how Wilson's disease affects dental health. Wilson's disease is a condition where the body has too much copper, which can lead to various health problems, including issues with teeth and gums. This study aims to compare the dental health of patients with two forms of Wilson's disease: the liver-related type and the neurological type, with a group of healthy individuals as a control. Researchers want to understand how these patients’ oral health differs and whether measuring copper levels in saliva can show if treatments are working.

To participate in this trial, individuals must be diagnosed with Wilson's disease or be part of the control group receiving a routine dental check-up. Participants should be between the ages of 65 and 74, and they need to agree to take part in the study. However, those who are pregnant, breastfeeding, or have severe mental health issues cannot join. If you decide to participate, you can expect to undergo dental assessments and provide saliva samples, which will help researchers gain insights into the oral health challenges faced by those with Wilson's disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Express consent to participate in the study
• • Member of or beneficiary of a social security scheme
• • For cases: Affected by Wilson's disease
• • For controls: Benefiting from a first routine dental consultation with dental panoramic imaging, outside of an emergency context or treatment follow-up/maintenance
• Exclusion Criteria:
• • Patient benefiting from a legal protection measure
• • Pregnant or breastfeeding women
• • Severe psychiatric disorders with behavioral disorders
• * For cases:
• • hepatic or neurological decompensation
• • liver transplant patient
• * For witnesses:
• • Patient with hepatic or neurological disease
• • Patient taking dietary supplements enriched with copper or zinc or zinc supplementation
• • Patient wearing removable prostheses with zinc-enriched prosthetic adhesives (Fixodent ProPlus®)