Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer
Launched by ABBVIE · Jun 30, 2022
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
The GLORIOSA clinical trial is studying a new treatment approach for patients with certain types of ovarian, fallopian tube, or peritoneal cancer who have responded well to previous platinum-based chemotherapy. The trial is comparing a medication called mirvetuximab soravtansine, combined with another drug called bevacizumab, to bevacizumab alone, to see if the combination is safer and more effective for maintaining health after initial treatment. This study is currently looking for participants aged 18 and older who have specific types of cancer that show a high level of a protein called folate receptor-alpha.
To be eligible, participants must have had a good response to their last treatment and meet certain health criteria. They will need to provide a sample of their tumor for testing and undergo some routine health checks. If chosen for the trial, participants can expect regular visits for treatment and monitoring, which includes scans and blood tests to track their progress. It’s important to note that this trial is specifically for patients who have already been treated with platinum-based chemotherapy and are considered "platinum-sensitive," meaning their cancer hasn’t progressed for more than six months after their last treatment.
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • 1. Adult women \>/=18 years old
- • 2. Confirmed diagnosis of high-grade serous epithelial ovarian, primary peritoneal, or fallopian tube cancer
- • 3. Confirmed high FRα expression by regulatory-agency approved Ventana FOLR1 (FOLR1-2.1)
- • 4. Relapsed disease after frontline (first-line) platinum-based chemotherapy and must be plantinum-sensitive
- • 5. Willing and able to sign the informed consent form (ICF) and adhere to protocol requirements
- • 6. Negative pregnancy test and willing to use highly effective contraceptive method(s) while on study medication and for at least 7 months after the last dose of MIRV and 6 months after the last dose of bevacizumab
- Exclusion Criteria:
- • 1. Endometrioid, clear cell, mucinous, or sarconmatous histology; mixed tumors containing any of the above or low grade/borderline ovarian tumor
- • 2. More than one line of prior chemotherapy before current/planned triplet therapy
- • 3. PD (progressive disease) while on or following platinum-based therapy
- • 4. Prior or whole-pelvis or wide-field radiotherapy
- • 5. \> Grade 1 peripheral neuropathy
- • 6. History of or concurrent ocular disorders
- • 7. Grade 4 thromboembolic events
- • 8. Not appropriate for bevacizumab treatment
- • 9. Requiring use of folate-containing supplements
- • 10. Prior hypersensitivity to monoclonal antibodies
- • 11. Pregnant or breatfeeding women
- • 12. Received prior MIRV or other FRα-targeting agents
- • 13. Untreated or symptomatic central nervous system metastases
- • 14. History of other malignancy within 3 years prior to signing study consent
About Abbvie
AbbVie is a global biopharmaceutical company dedicated to developing innovative therapies that address complex health challenges. Founded in 2013 as a spin-off from Abbott Laboratories, AbbVie focuses on key therapeutic areas, including immunology, oncology, neuroscience, and virology. The company is committed to advancing scientific research and delivering groundbreaking treatments that enhance patient outcomes and quality of life. With a robust pipeline and a strong emphasis on collaboration, AbbVie strives to transform the future of medicine through its commitment to clinical excellence and patient-centered approaches.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Columbus, Ohio, United States
Charlottesville, Virginia, United States
Lyon, , France
Seattle, Washington, United States
New Orleans, Louisiana, United States
Chicago, Illinois, United States
Valencia, , Spain
Cork, , Ireland
Dublin, , Ireland
Baltimore, Maryland, United States
Palo Alto, California, United States
Boston, Massachusetts, United States
New York, New York, United States
Miami, Florida, United States
Omaha, Nebraska, United States
Cincinnati, Ohio, United States
Fort Lauderdale, Florida, United States
Sarasota, Florida, United States
Iowa City, Iowa, United States
Westwood, Kansas, United States
Lexington, Kentucky, United States
Atlanta, Georgia, United States
Jacksonville, Florida, United States
Bologna, , Italy
Cheltenham, , United Kingdom
Hamilton, Ontario, Canada
La Jolla, California, United States
Lexington, Kentucky, United States
Westmead, , Australia
Barcelona, , Spain
Paris, , France
New Orleans, Louisiana, United States
Stockholm, , Sweden
Turku, , Finland
Dresden, , Germany
Ottawa, Ontario, Canada
Heidelberg, , Germany
Hamburg, , Germany
Kassel, , Germany
Iowa City, Iowa, United States
Baltimore, Maryland, United States
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Melbourne, Victoria, Australia
Stavanger, , Norway
Dijon, , France
Salvador, , Brazil
Málaga, , Spain
Brno, , Czechia
Scarborough, Maine, United States
Tianjin, Tianjin, China
Pavia, , Italy
Fuzhou, , China
Shizuoka, , Japan
Shanghai, Shanghai, China
Catania, , Italy
Baltimore, Maryland, United States
Hangzhou, , China
Honolulu, Hawaii, United States
Rio De Janeiro, , Brazil
Bonheiden, , Belgium
Charleroi, , Belgium
Oulu, , Finland
Dortmund, , Germany
Genova, , Italy
Mobile, Alabama, United States
Chapel Hill, North Carolina, United States
San Juan, , Philippines
Tromsø, , Norway
Toronto, Ontario, Canada
Hangzhou, Zhejiang, China
Zhengzhou, Henan, China
Córdoba, , Spain
Esslingen, , Germany
Hackensack, New Jersey, United States
Milano, , Italy
Porto Alegre, , Brazil
Sutton, Surrey, United Kingdom
Southport, Queensland, Australia
Richmond, Virginia, United States
Teaneck, New Jersey, United States
Concord, California, United States
Milano, , Italy
Seoul, , Korea, Republic Of
Zhengzhou, Henan, China
Athens, , Greece
Beijing, Beijing, China
Goyang, Gyeonggi Do, Korea, Republic Of
Seoul, , Korea, Republic Of
Strasbourg, , France
Fuzhou, Fujian, China
Chicago, Illinois, United States
Seoul, , Korea, Republic Of
Zhengzhou, , China
Wuhan, , China
Athens, , Greece
Lublin, , Poland
Rozzano, , Italy
Durham, North Carolina, United States
Montreal, Quebec, Canada
Jinan, Shandong, China
Firenze, , Italy
Hamburg, , Germany
Bonn, , Germany
Montreal, Quebec, Canada
Seoul, , Korea, Republic Of
Sapporo Shi, , Japan
Chiba Shi, , Japan
Niigata Shi, , Japan
Sendai Shi, , Japan
Harbin, Heilongjiang, China
Seongnam, Gyeonggi Do, Korea, Republic Of
Seoul, , Korea, Republic Of
Clayton, Victoria, Australia
Wuhan, Hubei, China
Changsha, Hunan, China
Caba, , Argentina
Shenyang, Liaoning, China
Oslo, , Norway
Tulsa, Oklahoma, United States
Xian, Shaanxi, China
Seoul, , Korea, Republic Of
Parma, , Italy
Swansea, , United Kingdom
Linyi, Shandong, China
Pittsburgh, Pennsylvania, United States
Ostrava Poruba, , Czechia
Guangzhou, Guangdong, China
Reẖovot, , Israel
Kettering, Ohio, United States
Erlangen, , Germany
Galway, , Ireland
Ramat Gan, , Israel
Roma, , Italy
Jinan, , China
Madrid, , Spain
Sligo, , Ireland
Swansea, Wales, United Kingdom
Gdynia, , Poland
Namur, , Belgium
Kielce, , Poland
Chuo Ku, , Japan
Isehara, , Japan
Jinan, Shandong, China
Waterford, , Ireland
Poznań, , Poland
Prague, , Czechia
Indianapolis, Indiana, United States
Sapporo, , Japan
London, , United Kingdom
Bengbu, Anhui, China
Oklahoma City, Oklahoma, United States
Kurume Shi, Hukuoka, Japan
Genova, , Italy
Maroúsi, , Greece
İzmir, , Turkey
Taiyuan, Shanxi, China
Okayama Shi, , Japan
Prague, , Czechia
Albany, New York, United States
Rosario, , Argentina
Seoul, Jongro Gu, Korea, Republic Of
Caba, , Argentina
Brussel, , Belgium
Koto Ku, , Japan
Marseille, , France
Changchun, , China
Barcelona, Barcelona [Barcelona], Spain
New York, New York, United States
Shanghai, , China
Nagoya Shi, , Japan
Surrey, British Columbia, Canada
Kunming, Yunnan, China
Germantown, Tennessee, United States
Petah Tikva, , Israel
Reno, Nevada, United States
Grand Rapids, Michigan, United States
Fort Myers, Florida, United States
Indianapolis, Indiana, United States
Springfield, Massachusetts, United States
Maplewood, Minnesota, United States
Paramus, New Jersey, United States
Albany, New York, United States
Mineola, New York, United States
New York, New York, United States
New York, New York, United States
Eugene, Oregon, United States
Portland, Oregon, United States
Austin, Texas, United States
Bedford, Texas, United States
Dallas, Texas, United States
Fort Worth, Texas, United States
San Antonio, Texas, United States
Norfolk, Virginia, United States
Calgary, Alberta, Canada
Vancouver, British Columbia, Canada
Ballarat, Victoria, Australia
Brighton, Victoria, Australia
Richmond, Victoria, Australia
Willow Grove, Pennsylvania, United States
Iloilo, , Philippines
Pasig, , Philippines
Quezon City, , Philippines
Subiaco, Western Australia, Australia
Irvine, California, United States
Orange, California, United States
Edmonton, Alberta, Canada
Montreal, Quebec, Canada
Sherbrooke, Quebec, Canada
Haifa, , Israel
Holon, , Israel
Jerusalem, , Israel
Jerusalem, , Israel
Kefar Sava, , Israel
Tel Aviv Yaffo, , Israel
Seongnam, Gyeonggi Do, Korea, Republic Of
Daegu, , Korea, Republic Of
Chengdu, Sichuan, China
Akashi Shi, , Japan
Essen, , Germany
Kingston, Ontario, Canada
Nanning, Guangxi, China
Thessaloníki, , Greece
San Diego, California, United States
Richmond, Virginia, United States
Nový Jicín, , Czechia
Lecco, , Italy
Lucca, , Italy
Meldola, , Italy
Mirano, , Italy
Piacenza, , Italy
Prato, , Italy
Rome, , Italy
Iloilo City, , Philippines
Pasig, , Philippines
Barcelona, , Spain
Coruña, , Spain
Girona, , Spain
Pamplona, , Spain
Fulham, London, United Kingdom
Northwood, , United Kingdom
Southampton, , United Kingdom
Irvine, California, United States
Los Angeles, California, United States
Riverside, California, United States
San Diego, California, United States
San Marcos, California, United States
Chicago, Illinois, United States
Hackensack, New Jersey, United States
Sioux Falls, South Dakota, United States
Bonheiden, , Belgium
Gent, , Belgium
Roeselare, , Belgium
Barcelona, , Spain
Barcelona, , Spain
Coruña, , Spain
Girona, , Spain
Girona, , Spain
Madrid, , Spain
Madrid, , Spain
Pamplona, , Spain
Valencia, , Spain
La Jolla, California, United States
Athens, , Greece
Phoenix, Arizona, United States
Irvine, California, United States
San Diego, California, United States
Sylmar, California, United States
Chicago, Illinois, United States
Lebanon, New Hampshire, United States
Portland, Oregon, United States
Subiaco, , Australia
Brussel, , Belgium
Charleroi, , Belgium
Leuven, , Belgium
Namur, , Belgium
Pasig, Metro Manila, Philippines
San Juan, Metro Manila, Philippines
Barcelona, , Spain
Madrid, , Spain
Bielefeld, , Germany
Jerusalem, , Israel
Pittsburgh, Pennsylvania, United States
Caba, , Argentina
Córdoba, , Argentina
Santa Fe, , Argentina
Barretos, , Brazil
Belo Horizonte, , Brazil
Cuiabá, , Brazil
Fortaleza, , Brazil
Itajaí, , Brazil
Porto Alegre, , Brazil
Recife, , Brazil
Rio De Janeiro, , Brazil
Salvador, , Brazil
São Paulo, , Brazil
São Paulo, , Brazil
São Paulo, , Brazil
Shumen, , Bulgaria
Vratsa, , Bulgaria
Aalborg, , Denmark
Copenhagen, , Denmark
Kuopio, , Finland
Brest, , France
Dijon, , France
Essen, , Germany
Giesen, , Germany
Mainz, , Germany
Munich, , Germany
Cork, , Ireland
Dublin, , Ireland
Jerusalem, , Israel
Ramat Gan, , Israel
Safed, , Israel
Napoli, , Italy
Reggio Emilia, , Italy
Kraków, , Poland
Poznań, , Poland
Siedlce, , Poland
Uppsala, , Sweden
Adana, , Turkey
Adana, , Turkey
Ankara, , Turkey
Ankara, , Turkey
Istanbul, , Turkey
Fulham, London, United Kingdom
Sutton, Surrey, United Kingdom
Manchester, , United Kingdom
Northwood, , United Kingdom
Beijing, , China
Beijing, , China
Bengbu, , China
Chengdu, , China
Guangzhou, , China
Guangzhou, , China
Hangzhou, , China
Jinan, , China
Kunming, , China
Linyi, , China
Naning, , China
Shenyang, , China
Taiyuan, , China
Tianjin, , China
Urumqi, , China
Xian, , China
Zhengzhou, , China
Milan, , Italy
Yahaba, , Japan
Mobile, Alabama, United States
Phoenix, Arizona, United States
Irvine, California, United States
La Jolla, California, United States
Orange, California, United States
Palo Alto, California, United States
San Diego, California, United States
San Diego, California, United States
San Marcos, California, United States
Sylmar, California, United States
Walnut Creek, California, United States
Fort Lauderdale, Florida, United States
Fort Myers, Florida, United States
Jacksonville, Florida, United States
Miami, Florida, United States
Sarasota, Florida, United States
Atlanta, Georgia, United States
Chicago, Illinois, United States
Chicago, Illinois, United States
Indianapolis, Indiana, United States
Indianapolis, Indiana, United States
Iowa City, Iowa, United States
Westwood, Kansas, United States
Lexington, Kentucky, United States
Lexington, Kentucky, United States
New Orleans, Louisiana, United States
New Orleans, Louisiana, United States
Scarborough, Maine, United States
Baltimore, Maryland, United States
Manchester, Maryland, United States
Towson, Maryland, United States
Boston, Massachusetts, United States
Springfield, Massachusetts, United States
Grand Rapids, Michigan, United States
Coon Rapids, Minnesota, United States
Omaha, Nebraska, United States
Reno, Nevada, United States
Lebanon, New Hampshire, United States
Hackensack, New Jersey, United States
Paramus, New Jersey, United States
Teaneck, New Jersey, United States
Albany, New York, United States
Albany, New York, United States
Lake Success, New York, United States
New York, New York, United States
New York, New York, United States
Chapel Hill, North Carolina, United States
Durham, North Carolina, United States
Cincinnati, Ohio, United States
Columbus, Ohio, United States
Kettering, Ohio, United States
Oklahoma City, Oklahoma, United States
Tulsa, Oklahoma, United States
Eugene, Oregon, United States
Portland, Oregon, United States
Portland, Oregon, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Willow Grove, Pennsylvania, United States
Sioux Falls, South Dakota, United States
Germantown, Tennessee, United States
Austin, Texas, United States
Bedford, Texas, United States
Dallas, Texas, United States
Fort Worth, Texas, United States
San Antonio, Texas, United States
Charlottesville, Virginia, United States
Norfolk, Virginia, United States
Richmond, Virginia, United States
Seattle, Washington, United States
Rosario, Santa Fe, Argentina
Buenos Aires, , Argentina
Cordoba, , Argentina
Santa Fe, , Argentina
Westmead, New South Wales, Australia
Southport, Queensland, Australia
Ballarat, Victoria, Australia
Clayton, Victoria, Australia
Malvern, Victoria, Australia
Melbourne, Victoria, Australia
Richmond, Victoria, Australia
Subiaco, Western Australia, Australia
Bonheiden, Antwerpen, Belgium
Bruxelles, Bruxelles Capitale, Belgium
Charleroi, Hainaut, Belgium
Gent, Oost Vlaanderen, Belgium
Leuven, Vlaams Brabant, Belgium
Roeselare, West Vlaanderen, Belgium
Namur, , Belgium
Shumen, , Bulgaria
Vratsa, , Bulgaria
Calgary, Alberta, Canada
Edmonton, Alberta, Canada
Surrey, British Columbia, Canada
Vancouver, British Columbia, Canada
Hamilton, Ontario, Canada
Kingston, Ontario, Canada
Ottawa, Ontario, Canada
Toronto, Ontario, Canada
Montreal, Quebec, Canada
Montreal, Quebec, Canada
Montreal, Quebec, Canada
Sherbrooke, Quebec, Canada
Beijing, Beijing, China
Guangzhou, Guangdong, China
Changsha, Hunan, China
Changchun, Jilin, China
Urumqi, Xinjiang, China
Hangzhou, Zhejiang, China
Brno, Brno Mesto, Czechia
Prague, Ceske Budejovice, Czechia
Nový Jičín, Novy Jicin, Czechia
Ostrava, Ostrava Mesto, Czechia
Marseille, Bouches Du Rhone, France
Dijon, Bourgogne Franche Comte, France
Brest, Finistere, France
Lyon Cedex 08, Rhone, France
Paris, , France
Strasbourg, , France
Esslingen Am Neckar, Baden Wuerttemberg, Germany
Erlangen, Bayern, Germany
Bonn, Nordrhein Westfalen, Germany
Dortmund, Nordrhein Westfalen, Germany
Dresden, Sachsen, Germany
Giessen, , Germany
Hamburg, , Germany
Panorama, Thessaloniki, Greece
Athens, , Greece
Athens, , Greece
Marousi, , Greece
Dublin 8, Dublin, Ireland
Cork, , Ireland
Cork, , Ireland
Dublin, , Ireland
Galway, , Ireland
Sligo, , Ireland
Waterford, , Ireland
Haifa, , Israel
Holon, Hamerkaz, Israel
Kfar Saba, Hamerkaz, Israel
Petah Tikva, Hamerkaz, Israel
Rekhovot, Hamerkaz, Israel
Ramat Gan, Tel Aviv, Israel
Tel Aviv, Tel Aviv, Israel
Jerusalem, , Israel
Jerusalem, , Israel
Safed, , Israel
Florence, Firenze, Italy
Genoa, Genova, Italy
Genoa, Genova, Italy
Rozzano, Lombardia, Italy
Milan, Milano, Italy
Milan, Milano, Italy
Naples, Napoli, Italy
Meldola, Reggio Emilia, Italy
Rome, Roma, Italy
Rome, Roma, Italy
Mirano, Venezia, Italy
Bologna, , Italy
Catania, , Italy
Lecco, , Italy
Lucca, , Italy
Parma, , Italy
Pavia, , Italy
Piacenza, , Italy
Prato, , Italy
Reggio Emilia, , Italy
Nagoya Shi, Aichi, Japan
Chiba Shi, Chiba, Japan
Matsuyama, Ehime, Japan
Kurume Shi, Fukuoka, Japan
Sapporo Shi, Hokkaido, Japan
Sapporo, Hokkaido, Japan
Akashi Shi, Hyogo, Japan
Yahaba, Iwate, Japan
Isehara, Kanagawa, Japan
Sendai Shi, Miyagi, Japan
Niigata Shi, Niigata, Japan
Okayama Shi, Okayama, Japan
Hidaka, Saitama, Japan
Sunto Gun, Shizuoka, Japan
Chuo Ku, Tokyo, Japan
Koto Ku, Tokyo, Japan
Minato Ku, Tokyo, Japan
Shinjuku Ku, Tokyo, Japan
Goyang Si, Gyeonggido, Korea, Republic Of
Seongnam Si, Gyeonggido, Korea, Republic Of
Seongnam, Gyeonggido, Korea, Republic Of
Daegu, Gyeongsangbugdo, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Pasig, National Capital Region, Philippines
Quezon City, National Capital Region, Philippines
San Juan City, National Capital Region, Philippines
Siedlce, Mazowieckie, Poland
Gdynia, Pomorskie, Poland
A Coruña, A Coruna, Spain
L'hospitalet De Llobregat, Barcelona, Spain
Pamplona, Navarra, Spain
Barcelona, , Spain
Barcelona, , Spain
Girona, , Spain
Madrid, , Spain
Madrid, , Spain
Valencia, , Spain
Ankara, , Turkey
Cheltenham, Gloucestershire, United Kingdom
London, Greater London, United Kingdom
London, Greater London, United Kingdom
Northwood, Greater London, United Kingdom
Southampton, Hampshire, United Kingdom
Sutton, Surrey, United Kingdom
Manchester, , United Kingdom
Swansea, , United Kingdom
Patients applied
Trial Officials
ABBVIE INC.
Study Director
AbbVie
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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