Comparison of Efficacy Between Nighttime and Daytime Peritoneal Dialysis

Launched by NANFANG HOSPITAL, SOUTHERN MEDICAL UNIVERSITY · Jul 3, 2022

Keywords

ClinConnect Summary

This clinical trial is looking to compare two methods of peritoneal dialysis (PD) called Continuous Ambulatory Peritoneal Dialysis (CAPD) and Automated Peritoneal Dialysis (APD) in patients who do not have diabetes. The goal is to see if patients feel the same quality of life and receive effective dialysis with either method. Researchers will involve 268 participants who have been on PD for at least one month, are between 18 and 75 years old, and meet certain health criteria. Unfortunately, those with diabetes, recent heart issues, or specific other health conditions will not be eligible.

If you decide to participate, you will be randomly assigned to one of two groups. For the first 12 weeks, one group will use APD while the other uses CAPD. Then, they will switch methods for the next 12 weeks. The researchers will check how you are doing at the end of each 12-week period. This trial is currently recruiting participants, and it is an important step in understanding which dialysis method may be better for patients without diabetes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age 18 to 75 years;
• • 2. Maintenance peritoneal dialysis for ≥ 1 month;
• • 3. Weekly total CrCL ≥ 45 liters/week/1.73m2 body surface area;
• • 4. Total weekly Kt/V ≥ 1.7.
• Exclusion Criteria:
• • 1. Patients with diabetes mellitus;
• • 2. Maintained peritoneal dialysis solution with a glucose concentration \>2.5%;
• • 3. Combined with acute events of cardiovascular disease(CVD), cardiac function ≥ New York Heart Association (NYHA) class III;
• • 4. Episodes of peritonitis in the past 1 month;
• • 5. Abdominal surgery other than PD catheter insertion in the past 3 months;
• • 6. Planned kidney transplant in the last 6 months;
• • 7. Active hepatitis, cirrhosis, psychiatric disease, malignancy, pregnancy.