The Effects of Vitamin D Plus Omega-3 Polyunsaturated Fatty Acids in Patients With Episodic Migraine

Launched by KUANG TIEN GENERAL HOSPITAL · Jul 7, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the effects of vitamin D and omega-3 fatty acids in people who experience episodic migraines, which are headaches that happen 4 to 15 days a month. The researchers want to find out if taking vitamin D helps reduce the number of migraines, and if combining vitamin D with omega-3 fatty acids (found in fish oil) is more effective than taking a placebo (a non-active treatment) along with omega-3s.

To participate, you should be between 20 and 65 years old, have been diagnosed with episodic migraines, and have low levels of vitamin D in your blood. However, certain conditions would exclude you from joining, such as having other types of headaches, serious health issues, or allergies to fish. If you qualify and choose to participate, you will be helping researchers understand how these supplements might help with migraine prevention while also monitoring your symptoms. Your involvement could contribute to new ways of managing migraines for many people.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Aged 20-65 years
• • 2. Episodic migraine diagnosis with ICHD-3
• • 3. Baseline migraine days between 4 and 15 days per month
• • 4. Episodic migraine without or without aura
• • 5. Blood Vit D\< 30ng/mL at baseline
• • 6. With completed informed consent
• Exclusion Criteria:
• • 1. Non-migraine (ex: tension-type headache or secondary headache)
• • 2. Having major head trauma in the past
• • 3. Alcoholism within 1 year
• • 4. Patients with abnormal liver and kidney function and patients with other serious diseases such as infection with any inflammation
• • 5. Pregnant women or women who are still breastfeeding
• • 6. Those who are unable to cooperate with the progress of the trial and who have participated in other clinical studies.
• • 7. Patients with abnormal coagulation function or taking anticoagulant drugs
• • 8. Weight \< 45 kg or \> 80 kg
• • 9. Abnormal parathyroid function, intestinal dysfunction, hypercalcemia (total calcium ion concentration in blood\> 2.6 mmol/L)
• • 10. Conditions with high risk of hypercalcemia, such as: Metastatic cancer, Sarcoidosis, Multiple myeloma, Primary hyperparathyroidism
• • 11. Those who are allergic to fish or fish oil
• • 12. Vegetarian
• • 13. Taking beta-blockers, antiepileptic drugs, calcium ion blockers, antidepressants or hormonal preparations in the past month
• • 14. Using vitamin D (\> 3000 IU/day), calcium tablets, estrogen drugs, bisphosphonates, and other drugs to treat bone diseases.