Filter Lifespan in Continuous Renal Replacement Therapy

Launched by UNIVERSITY HOSPITAL MUENSTER · Jul 5, 2022

Keywords

ClinConnect Summary

This clinical trial, titled "Filter Lifespan in Continuous Renal Replacement Therapy," is investigating how the lifespan of filters used in a specific type of kidney treatment called Continuous Renal Replacement Therapy (CRRT) relates to the development of new infections in critically ill patients. CRRT is often used for patients with acute kidney injury (AKI), which means their kidneys are not working properly and they need support to remove waste from their blood. The study aims to understand why patients who have longer-lasting filters might be more likely to develop infections, even though the type of blood thinner used during treatment doesn’t seem to affect infection rates.

To participate in the trial, you must be at least 18 years old and currently receiving CRRT due to dialysis-dependent AKI. Unfortunately, if you have chronic kidney disease, are on long-term dialysis, or have certain other health conditions, you won’t be eligible. If you join the study, you'll be closely monitored, and your experiences will help researchers learn more about the risks of infection in critically ill patients receiving this type of treatment. The trial is currently recruiting participants, and anyone interested will need to give their written consent to take part.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (age ≥18 years)
• • Critically ill patients with dialysis-dependent AKI
• • Continuous renal replacement therapy (CRRT)
• • Written informed consent
• Exclusion Criteria:
• • Chronic kidney disease with estimated glomerular filtration rate (eGFR)\<30ml/min/1.73m2
• • Chronic dialysis dependency
• • Kidney transplant
• • (Glomerulo-)nephritis, interstitial nephritis, vasculitis
• • Patients on immunosuppression
• • Patients with chronic inflammatory diseases (e.g. arthritis, HIV, chronic hepatitis)
• • Persons with any kind of dependency on the investigator or employed by the sponsor or investigator