Factors in Learning and Plasticity: Macular Degeneration
Launched by UNIVERSITY OF ALABAMA AT BIRMINGHAM · Jul 7, 2022
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is exploring how the brain adapts and learns after a person experiences significant vision loss, particularly due to macular degeneration. By understanding these changes, researchers hope to develop new therapies that could help millions of people with low vision. The trial aims to compare different training methods to see which ones might lead to better visual outcomes for participants.
To be eligible for the study, participants need to be between 18 and 89 years old and have severely impaired vision in both eyes, with a diagnosis of macular degeneration. They should also have had this level of vision loss for at least two years and live within 50 miles of the study site. Participants can expect to engage in training that could help improve their visual abilities, and the study is currently looking for volunteers. It's important to note that individuals with certain medical conditions or implants, as well as those who are pregnant or have specific mental health concerns, may not be eligible to participate.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Aged 18-89
- • Severely impaired vision in both eyes (20/100 or worse)
- • diagnosis of Macular Degeneration by an Ophthalmologist
- • Light sensitivity in the macular retina that is at least 10 dB units worse than in peripheral regions, as demonstrated by a scanning laser ophthalmoscope (MAIA)
- • Medical record review indicating this level of disease severity has been present for at least 2 years
- • Reside within 50 miles of study site
- Exclusion Criteria:
- • Pacemaker or any ferromagnetic metal implanted in their body
- • Metal of any type implanted in their head (limited dental work is acceptable)
- • Claustrophobia
- • Being hearing-impaired
- • Weight over 300 pounds
- • Maximum body girth over 60 inches
- • Previous serious head injury
- • Presence of hallucinations or delusions
- • Excessive old, or colorful tattoos, especially near the head
- • Pregnancy
- • Braces/permanent retainer
About University Of Alabama At Birmingham
The University of Alabama at Birmingham (UAB) is a prominent academic institution and research hub dedicated to advancing healthcare through innovative clinical trials. Renowned for its commitment to medical discovery and education, UAB conducts cutting-edge research across a wide array of disciplines, including oncology, cardiology, neurology, and public health. With a robust infrastructure for clinical research, UAB fosters collaboration among interdisciplinary teams, leveraging state-of-the-art facilities and resources to enhance the translation of scientific findings into effective treatments and interventions. As a leader in clinical research, UAB aims to improve patient outcomes and contribute to the broader medical community through rigorous trial design and implementation.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Birmingham, Alabama, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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